Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.

Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas.

Germline mutations in the LKB1/STK11 gene cause characteristic hamartomas and freckling to develop in patients with Peutz-Jeghers syndrome (PJS). The hamartomas arise as a result of somatic "second hits" at LKB1/STK11 and therefore contain a neoplastic element. The origin of the pigmented...

书目详细资料
Main Authors:	Rowan, A, Bataille, V, MacKie, R, Healy, E, Bicknell, D, Bodmer, W, Tomlinson, I
格式:	Journal article
语言:	English
出版:	1999

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