Translesion synthesis: Y-family polymerases and the polymerase switch.

Translesion synthesis: Y-family polymerases and the polymerase switch.

Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities...

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Bibliographic Details
Main Authors: Lehmann, A, Niimi, A, Ogi, T, Brown, S, Sabbioneda, S, Wing, J, Kannouche, P, Green, C
Format: Journal article
Language:English
Published: 2007
Description
Summary:Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage. In eukaryotes mono-ubiquitination of PCNA plays a crucial role in the switch from replicative to TLS polymerases at stalled forks. All the Y-family polymerases have ubiquitin binding sites that increase their binding affinity for ubiquitinated PCNA at the sites of stalled forks.

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