Translesion synthesis: Y-family polymerases and the polymerase switch.
Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2007
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| _version_ | 1797101389235617792 |
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| author | Lehmann, A Niimi, A Ogi, T Brown, S Sabbioneda, S Wing, J Kannouche, P Green, C |
| author_facet | Lehmann, A Niimi, A Ogi, T Brown, S Sabbioneda, S Wing, J Kannouche, P Green, C |
| author_sort | Lehmann, A |
| collection | OXFORD |
| description | Replicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage. In eukaryotes mono-ubiquitination of PCNA plays a crucial role in the switch from replicative to TLS polymerases at stalled forks. All the Y-family polymerases have ubiquitin binding sites that increase their binding affinity for ubiquitinated PCNA at the sites of stalled forks. |
| first_indexed | 2024-03-07T05:51:12Z |
| format | Journal article |
| id | oxford-uuid:e8f0581f-3cd0-4d03-b54b-4ec731ed615f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:51:12Z |
| publishDate | 2007 |
| record_format | dspace |
| spelling | oxford-uuid:e8f0581f-3cd0-4d03-b54b-4ec731ed615f2022-03-27T10:50:33ZTranslesion synthesis: Y-family polymerases and the polymerase switch.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e8f0581f-3cd0-4d03-b54b-4ec731ed615fEnglishSymplectic Elements at Oxford2007Lehmann, ANiimi, AOgi, TBrown, SSabbioneda, SWing, JKannouche, PGreen, CReplicative DNA polymerases are blocked at DNA lesions. Synthesis past DNA damage requires the replacement of the replicative polymerase by one of a group of specialised translesion synthesis (TLS) polymerases, most of which belong to the Y-family. Each of these has different substrate specificities for different types of damage. In eukaryotes mono-ubiquitination of PCNA plays a crucial role in the switch from replicative to TLS polymerases at stalled forks. All the Y-family polymerases have ubiquitin binding sites that increase their binding affinity for ubiquitinated PCNA at the sites of stalled forks. |
| spellingShingle | Lehmann, A Niimi, A Ogi, T Brown, S Sabbioneda, S Wing, J Kannouche, P Green, C Translesion synthesis: Y-family polymerases and the polymerase switch. |
| title | Translesion synthesis: Y-family polymerases and the polymerase switch. |
| title_full | Translesion synthesis: Y-family polymerases and the polymerase switch. |
| title_fullStr | Translesion synthesis: Y-family polymerases and the polymerase switch. |
| title_full_unstemmed | Translesion synthesis: Y-family polymerases and the polymerase switch. |
| title_short | Translesion synthesis: Y-family polymerases and the polymerase switch. |
| title_sort | translesion synthesis y family polymerases and the polymerase switch |
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