The relationship between invasive nontyphoidal salmonella disease, other bacterial bloodstream infections, and malaria in Sub-Saharan Africa
Country-specific studies in Africa have indicated that Plasmodium falciparum is associated with invasive nontyphoidal Salmonella (iNTS) disease. We conducted a multicenter study in 13 sites in Burkina Faso, Ethiopia, Ghana, Guinea-Bissau, Kenya, Madagascar, Senegal, South Africa, Sudan, and Tanzania...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2016
|
| _version_ | 1826302685645635584 |
|---|---|
| author | Park, SE Pak, G Aaby, P Adu-Sarkodie, Y Ali, M Aseffa, A Biggs, H Bjerregaard-Andersen, M Breiman, R Crump, J Cruz Espinoza, L Eltayeb, M Gasmelseed, N Hertz, J Im, J Jaeger, A Parfait Kabore, L von Kalckreuth, V Keddy, K Konings, F Krumkamp, R MacLennan, C Meyer, C Montgomery, J Ahmet Niang, A Nichols, C Olack, B Panzner, U Park, J Rabezanahary, H Rakotozandrindrainy, R Sampo, E Sarpong, N Schütt-Gerowitt, H Sooka, A Soura, AB Sow, A Tall, A Teferi, M Yeshitela, B May, J Wierzba, T Clemens, J Baker, S Marks, F |
| author_facet | Park, SE Pak, G Aaby, P Adu-Sarkodie, Y Ali, M Aseffa, A Biggs, H Bjerregaard-Andersen, M Breiman, R Crump, J Cruz Espinoza, L Eltayeb, M Gasmelseed, N Hertz, J Im, J Jaeger, A Parfait Kabore, L von Kalckreuth, V Keddy, K Konings, F Krumkamp, R MacLennan, C Meyer, C Montgomery, J Ahmet Niang, A Nichols, C Olack, B Panzner, U Park, J Rabezanahary, H Rakotozandrindrainy, R Sampo, E Sarpong, N Schütt-Gerowitt, H Sooka, A Soura, AB Sow, A Tall, A Teferi, M Yeshitela, B May, J Wierzba, T Clemens, J Baker, S Marks, F |
| author_sort | Park, SE |
| collection | OXFORD |
| description | Country-specific studies in Africa have indicated that Plasmodium falciparum is associated with invasive nontyphoidal Salmonella (iNTS) disease. We conducted a multicenter study in 13 sites in Burkina Faso, Ethiopia, Ghana, Guinea-Bissau, Kenya, Madagascar, Senegal, South Africa, Sudan, and Tanzania to investigate the relationship between the occurrence of iNTS disease, other systemic bacterial infections, and malaria.Febrile patients received a blood culture and a malaria test. Isolated bacteria underwent antimicrobial susceptibility testing, and the association between iNTS disease and malaria was assessed.A positive correlation between frequency proportions of malaria and iNTS was observed (P = .01; r = 0.70). Areas with higher burden of malaria exhibited higher odds of iNTS disease compared to other bacterial infections (odds ratio [OR], 4.89; 95% CI, 1.61-14.90; P = .005) than areas with lower malaria burden. Malaria parasite positivity was associated with iNTS disease (OR, 2.44; P = .031) and gram-positive bacteremias, particularly Staphylococcus aureus, exhibited a high proportion of coinfection with Plasmodium malaria. Salmonella Typhimurium and Salmonella Enteritidis were the predominant NTS serovars (53/73; 73%). Both moderate (OR, 6.05; P = .0001) and severe (OR, 14.62; P < .0001) anemia were associated with iNTS disease.A positive correlation between iNTS disease and malaria endemicity, and the association between Plasmodium parasite positivity and iNTS disease across sub-Saharan Africa, indicates the necessity to consider iNTS as a major cause of febrile illness in malaria-holoendemic areas. Prevention of iNTS disease through iNTS vaccines for areas of high malaria endemicity, targeting high-risk groups for Plasmodium parasitic infection, should be considered. |
| first_indexed | 2024-03-07T05:51:18Z |
| format | Journal article |
| id | oxford-uuid:e8f9ed49-21f1-452c-8a60-5ad67dc750f3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:51:18Z |
| publishDate | 2016 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:e8f9ed49-21f1-452c-8a60-5ad67dc750f32022-03-27T10:50:58ZThe relationship between invasive nontyphoidal salmonella disease, other bacterial bloodstream infections, and malaria in Sub-Saharan AfricaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e8f9ed49-21f1-452c-8a60-5ad67dc750f3EnglishSymplectic Elements at OxfordOxford University Press2016Park, SEPak, GAaby, PAdu-Sarkodie, YAli, MAseffa, ABiggs, HBjerregaard-Andersen, MBreiman, RCrump, JCruz Espinoza, LEltayeb, MGasmelseed, NHertz, JIm, JJaeger, AParfait Kabore, Lvon Kalckreuth, VKeddy, KKonings, FKrumkamp, RMacLennan, CMeyer, CMontgomery, JAhmet Niang, ANichols, COlack, BPanzner, UPark, JRabezanahary, HRakotozandrindrainy, RSampo, ESarpong, NSchütt-Gerowitt, HSooka, ASoura, ABSow, ATall, ATeferi, MYeshitela, BMay, JWierzba, TClemens, JBaker, SMarks, FCountry-specific studies in Africa have indicated that Plasmodium falciparum is associated with invasive nontyphoidal Salmonella (iNTS) disease. We conducted a multicenter study in 13 sites in Burkina Faso, Ethiopia, Ghana, Guinea-Bissau, Kenya, Madagascar, Senegal, South Africa, Sudan, and Tanzania to investigate the relationship between the occurrence of iNTS disease, other systemic bacterial infections, and malaria.Febrile patients received a blood culture and a malaria test. Isolated bacteria underwent antimicrobial susceptibility testing, and the association between iNTS disease and malaria was assessed.A positive correlation between frequency proportions of malaria and iNTS was observed (P = .01; r = 0.70). Areas with higher burden of malaria exhibited higher odds of iNTS disease compared to other bacterial infections (odds ratio [OR], 4.89; 95% CI, 1.61-14.90; P = .005) than areas with lower malaria burden. Malaria parasite positivity was associated with iNTS disease (OR, 2.44; P = .031) and gram-positive bacteremias, particularly Staphylococcus aureus, exhibited a high proportion of coinfection with Plasmodium malaria. Salmonella Typhimurium and Salmonella Enteritidis were the predominant NTS serovars (53/73; 73%). Both moderate (OR, 6.05; P = .0001) and severe (OR, 14.62; P < .0001) anemia were associated with iNTS disease.A positive correlation between iNTS disease and malaria endemicity, and the association between Plasmodium parasite positivity and iNTS disease across sub-Saharan Africa, indicates the necessity to consider iNTS as a major cause of febrile illness in malaria-holoendemic areas. Prevention of iNTS disease through iNTS vaccines for areas of high malaria endemicity, targeting high-risk groups for Plasmodium parasitic infection, should be considered. |
| spellingShingle | Park, SE Pak, G Aaby, P Adu-Sarkodie, Y Ali, M Aseffa, A Biggs, H Bjerregaard-Andersen, M Breiman, R Crump, J Cruz Espinoza, L Eltayeb, M Gasmelseed, N Hertz, J Im, J Jaeger, A Parfait Kabore, L von Kalckreuth, V Keddy, K Konings, F Krumkamp, R MacLennan, C Meyer, C Montgomery, J Ahmet Niang, A Nichols, C Olack, B Panzner, U Park, J Rabezanahary, H Rakotozandrindrainy, R Sampo, E Sarpong, N Schütt-Gerowitt, H Sooka, A Soura, AB Sow, A Tall, A Teferi, M Yeshitela, B May, J Wierzba, T Clemens, J Baker, S Marks, F The relationship between invasive nontyphoidal salmonella disease, other bacterial bloodstream infections, and malaria in Sub-Saharan Africa |
| title | The relationship between invasive nontyphoidal salmonella disease, other bacterial bloodstream infections, and malaria in Sub-Saharan Africa |
| title_full | The relationship between invasive nontyphoidal salmonella disease, other bacterial bloodstream infections, and malaria in Sub-Saharan Africa |
| title_fullStr | The relationship between invasive nontyphoidal salmonella disease, other bacterial bloodstream infections, and malaria in Sub-Saharan Africa |
| title_full_unstemmed | The relationship between invasive nontyphoidal salmonella disease, other bacterial bloodstream infections, and malaria in Sub-Saharan Africa |
| title_short | The relationship between invasive nontyphoidal salmonella disease, other bacterial bloodstream infections, and malaria in Sub-Saharan Africa |
| title_sort | relationship between invasive nontyphoidal salmonella disease other bacterial bloodstream infections and malaria in sub saharan africa |
| work_keys_str_mv | AT parkse therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT pakg therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT aabyp therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT adusarkodiey therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT alim therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT aseffaa therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT biggsh therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT bjerregaardandersenm therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT breimanr therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT crumpj therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT cruzespinozal therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT eltayebm therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT gasmelseedn therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT hertzj therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT imj therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT jaegera therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT parfaitkaborel therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT vonkalckreuthv therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT keddyk therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT koningsf therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT krumkampr therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT maclennanc therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT meyerc therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT montgomeryj therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT ahmetnianga therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT nicholsc therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT olackb therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT panzneru therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT parkj therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT rabezanaharyh therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT rakotozandrindrainyr therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT sampoe therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT sarpongn therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT schuttgerowitth therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT sookaa therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT souraab therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT sowa therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT talla therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT teferim therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT yeshitelab therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT mayj therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT wierzbat therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT clemensj therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT bakers therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT marksf therelationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT parkse relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT pakg relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT aabyp relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT adusarkodiey relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT alim relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT aseffaa relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT biggsh relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT bjerregaardandersenm relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT breimanr relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT crumpj relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT cruzespinozal relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT eltayebm relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT gasmelseedn relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT hertzj relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT imj relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT jaegera relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT parfaitkaborel relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT vonkalckreuthv relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT keddyk relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT koningsf relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT krumkampr relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT maclennanc relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT meyerc relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT montgomeryj relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT ahmetnianga relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT nicholsc relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT olackb relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT panzneru relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT parkj relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT rabezanaharyh relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT rakotozandrindrainyr relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT sampoe relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT sarpongn relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT schuttgerowitth relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT sookaa relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT souraab relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT sowa relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT talla relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT teferim relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT yeshitelab relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT mayj relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT wierzbat relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT clemensj relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT bakers relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica AT marksf relationshipbetweeninvasivenontyphoidalsalmonelladiseaseotherbacterialbloodstreaminfectionsandmalariainsubsaharanafrica |