Glucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production.
To evaluate glucose kinetics in children with falciparum malaria, basal glucose production and gluconeogenesis and an estimate of the flux of the gluconeogenic precursors were measured in Kenyan children with uncomplicated falciparum malaria before (n = 11) and during infusion of alanine (1.5 mg/kg....
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1997
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| _version_ | 1826302686044094464 |
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| author | Dekker, E Hellerstein, M Romijn, J Neese, R Peshu, N Endert, E Marsh, K Sauerwein, H |
| author_facet | Dekker, E Hellerstein, M Romijn, J Neese, R Peshu, N Endert, E Marsh, K Sauerwein, H |
| author_sort | Dekker, E |
| collection | OXFORD |
| description | To evaluate glucose kinetics in children with falciparum malaria, basal glucose production and gluconeogenesis and an estimate of the flux of the gluconeogenic precursors were measured in Kenyan children with uncomplicated falciparum malaria before (n = 11) and during infusion of alanine (1.5 mg/kg.min; n = 6). Glucose production was measured by [6,6-2H2]glucose, gluconeogenesis by mass isotopomer distribution analysis of glucose labeled by [2-13C]glycerol. Basal plasma glucose concentration ranged from 2.1-5.5 mmol/L, and basal glucose production ranged from 3.3-7.3 mg/kg.min. Glucose production was largely derived from gluconeogenesis (73 +/- 4%; range, 52-93%). During alanine infusion, plasma glucose increased by 0.4 mmol/L (P = 0.03), glucose production increased by 0.8 mg/kg.min (P = 0.02), and gluconeogenesis increased by 0.8 mg/kg.min (P = 0.04). We conclude that glucose production in children with uncomplicated falciparum malaria is largely dependent on gluconeogenesis. However, gluconeogenesis is potentially limited by insufficient precursor supply. These data indicate that in children with falciparum malaria, gluconeogenesis fails to compensate in the presence of decreased glycogen flux to glucose, increasing the risk of hypoglycemia. |
| first_indexed | 2024-03-07T05:51:19Z |
| format | Journal article |
| id | oxford-uuid:e8fa242e-d7e7-47de-b8c4-a2fd17a6c072 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:51:19Z |
| publishDate | 1997 |
| record_format | dspace |
| spelling | oxford-uuid:e8fa242e-d7e7-47de-b8c4-a2fd17a6c0722022-03-27T10:50:48ZGlucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e8fa242e-d7e7-47de-b8c4-a2fd17a6c072EnglishSymplectic Elements at Oxford1997Dekker, EHellerstein, MRomijn, JNeese, RPeshu, NEndert, EMarsh, KSauerwein, HTo evaluate glucose kinetics in children with falciparum malaria, basal glucose production and gluconeogenesis and an estimate of the flux of the gluconeogenic precursors were measured in Kenyan children with uncomplicated falciparum malaria before (n = 11) and during infusion of alanine (1.5 mg/kg.min; n = 6). Glucose production was measured by [6,6-2H2]glucose, gluconeogenesis by mass isotopomer distribution analysis of glucose labeled by [2-13C]glycerol. Basal plasma glucose concentration ranged from 2.1-5.5 mmol/L, and basal glucose production ranged from 3.3-7.3 mg/kg.min. Glucose production was largely derived from gluconeogenesis (73 +/- 4%; range, 52-93%). During alanine infusion, plasma glucose increased by 0.4 mmol/L (P = 0.03), glucose production increased by 0.8 mg/kg.min (P = 0.02), and gluconeogenesis increased by 0.8 mg/kg.min (P = 0.04). We conclude that glucose production in children with uncomplicated falciparum malaria is largely dependent on gluconeogenesis. However, gluconeogenesis is potentially limited by insufficient precursor supply. These data indicate that in children with falciparum malaria, gluconeogenesis fails to compensate in the presence of decreased glycogen flux to glucose, increasing the risk of hypoglycemia. |
| spellingShingle | Dekker, E Hellerstein, M Romijn, J Neese, R Peshu, N Endert, E Marsh, K Sauerwein, H Glucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production. |
| title | Glucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production. |
| title_full | Glucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production. |
| title_fullStr | Glucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production. |
| title_full_unstemmed | Glucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production. |
| title_short | Glucose homeostasis in children with falciparum malaria: precursor supply limits gluconeogenesis and glucose production. |
| title_sort | glucose homeostasis in children with falciparum malaria precursor supply limits gluconeogenesis and glucose production |
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