Pleural infection: moving from treatment to prevention

The incidence of pleural infection is rising, and most clearly in the elderly, where it is associated with the highest mortality. Despite notable limitations in animal models replicating the human pleural space, there has been some progress in our understanding of the evolution of pleural infection....

Popoln opis

Bibliografske podrobnosti
Main Authors: Bedawi, EO, Rahman, NM
Format: Journal article
Jezik:English
Izdano: European Respiratory Society 2020
_version_ 1826302689445675008
author Bedawi, EO
Rahman, NM
author_facet Bedawi, EO
Rahman, NM
author_sort Bedawi, EO
collection OXFORD
description The incidence of pleural infection is rising, and most clearly in the elderly, where it is associated with the highest mortality. Despite notable limitations in animal models replicating the human pleural space, there has been some progress in our understanding of the evolution of pleural infection. Studies continue to demonstrate that the microbiology is inherently different from pneumonia, emphasising that this is a distinct disease. Great headway has been made in the last decade with regard to optimising drainage. The place of intrapleural enzyme therapy in the therapeutic armamentarium is growing in importance, with research efforts now focused on optimising dosing, administration and exploring new targets. Surgery continues to play an important role, but timing and patient selection remain unclear. An increased awareness of at-risk groups coupled with early aggressive management strategies supported by risk stratification at the time of presentation are likely to be essential components in aiding the healthcare community to improve outcomes of this morbid condition.
first_indexed 2024-03-07T05:51:22Z
format Journal article
id oxford-uuid:e8fe9255-3e47-4e28-a64d-c40cae11c160
institution University of Oxford
language English
last_indexed 2024-03-07T05:51:22Z
publishDate 2020
publisher European Respiratory Society
record_format dspace
spelling oxford-uuid:e8fe9255-3e47-4e28-a64d-c40cae11c1602022-03-27T10:50:58ZPleural infection: moving from treatment to preventionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e8fe9255-3e47-4e28-a64d-c40cae11c160EnglishSymplectic ElementsEuropean Respiratory Society2020Bedawi, EORahman, NMThe incidence of pleural infection is rising, and most clearly in the elderly, where it is associated with the highest mortality. Despite notable limitations in animal models replicating the human pleural space, there has been some progress in our understanding of the evolution of pleural infection. Studies continue to demonstrate that the microbiology is inherently different from pneumonia, emphasising that this is a distinct disease. Great headway has been made in the last decade with regard to optimising drainage. The place of intrapleural enzyme therapy in the therapeutic armamentarium is growing in importance, with research efforts now focused on optimising dosing, administration and exploring new targets. Surgery continues to play an important role, but timing and patient selection remain unclear. An increased awareness of at-risk groups coupled with early aggressive management strategies supported by risk stratification at the time of presentation are likely to be essential components in aiding the healthcare community to improve outcomes of this morbid condition.
spellingShingle Bedawi, EO
Rahman, NM
Pleural infection: moving from treatment to prevention
title Pleural infection: moving from treatment to prevention
title_full Pleural infection: moving from treatment to prevention
title_fullStr Pleural infection: moving from treatment to prevention
title_full_unstemmed Pleural infection: moving from treatment to prevention
title_short Pleural infection: moving from treatment to prevention
title_sort pleural infection moving from treatment to prevention
work_keys_str_mv AT bedawieo pleuralinfectionmovingfromtreatmenttoprevention
AT rahmannm pleuralinfectionmovingfromtreatmenttoprevention