Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.
Refined crystal structures are reported for complexes of Escherichia coli and chicken dihydrofolate reductase containing the antibiotic trimethoprim (TMP). Structural comparison of these two complexes reveals major geometrical differences in TMP binding that may be important in understanding the ste...
Үндсэн зохиолчид: | Matthews, D, Bolin, J, Burridge, J, Filman, D, Volz, K, Kaufman, B, Beddell, C, Champness, J, Stammers, D, Kraut, J |
---|---|
Формат: | Journal article |
Хэл сонгох: | English |
Хэвлэсэн: |
1985
|
Ижил төстэй зүйлс
Ижил төстэй зүйлс
-
The binding of trimethoprim to bacterial dihydrofolate reductase.
-н: Baker, D, зэрэг
Хэвлэсэн: (1981) -
Crystallographic investigation of the cooperative interaction between trimethoprim, reduced cofactor and dihydrofolate reductase.
-н: Champness, J, зэрэг
Хэвлэсэн: (1986) -
Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.
-н: Kuyper, L, зэрэг
Хэвлэсэн: (1985) -
Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.
-н: Kuyper, L, зэрэг
Хэвлэсэн: (1982) -
The structure of mouse L1210 dihydrofolate reductase-drug complexes and the construction of a model of human enzyme.
-н: Stammers, D, зэрэг
Хэвлэсэн: (1987)