Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.

Refined crystal structures of Escherichia coli and chicken liver dihydrofolate reductase containing bound trimethoprim.

Refined crystal structures are reported for complexes of Escherichia coli and chicken dihydrofolate reductase containing the antibiotic trimethoprim (TMP). Structural comparison of these two complexes reveals major geometrical differences in TMP binding that may be important in understanding the ste...

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Bibliographic Details
Main Authors:	Matthews, D, Bolin, J, Burridge, J, Filman, D, Volz, K, Kaufman, B, Beddell, C, Champness, J, Stammers, D, Kraut, J
Format:	Journal article
Language:	English
Published:	1985

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