Discovery of a potent dual SLK/STK10 inhibitor based on a maleimide scaffold

Discovery of a potent dual SLK/STK10 inhibitor based on a maleimide scaffold

SLK (STE20-like kinase) and STK10 (serine/threonine kinase 10) are closely related kinases whose enzymatic activity is linked to the regulation of ezrin, radixin, and moesin function and to the regulation of lymphocyte migration and the cell cycle. We identified a series of 3-anilino-4-arylmaleimide...

Полное описание

Библиографические подробности
Главные авторы:	Serafim, RAM, Sorrell, FJ, Berger, B-T, Collins, RJ, Vasconcelos, SNS, Massirer, KB, Knapp, S, Bennett, J, Fedorov, O, Patel, H, Zuercher, WJ, Elkins, JM
Формат:	Journal article
Язык:	English
Опубликовано:	American Chemical Society 2021

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