A systematic review of the association between dementia risk factors and cerebrovascular reactivity
<p>Cumulative evidence suggests that impaired cerebrovascular reactivity (CVR), a regulatory response critical for maintaining neuronal health, is amongst the earliest pathological changes in dementia. However, we know little about how CVR is affected by dementia risk, prior to disease onset....
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2023
|
| _version_ | 1826310357297135616 |
|---|---|
| author | Wang, C Reid, G Mackay, CE Hayes, G Bulte, DP Suri, S |
| author_facet | Wang, C Reid, G Mackay, CE Hayes, G Bulte, DP Suri, S |
| author_sort | Wang, C |
| collection | OXFORD |
| description | <p>Cumulative evidence suggests that impaired cerebrovascular reactivity (CVR), a regulatory response critical for maintaining neuronal health, is amongst the earliest pathological changes in dementia. However, we know little about how CVR is affected by dementia risk, prior to disease onset. Understanding this relationship would improve our knowledge of disease pathways and help inform preventative interventions. This systematic review investigates 59 studies examining how CVR (measured by magnetic resonance imaging) is affected by modifiable, non-modifiable, and clinical risk factors for dementia. We report that non-modifiable risk (older age and apolipoprotein ε4), some modifiable factors (diabetes, traumatic brain injury, hypertension) and some clinical factors (stroke, carotid artery occlusion, stenosis) were consistently associated with reduced CVR. We also note a lack of conclusive evidence on how other behavioural factors such as physical inactivity, obesity, or depression, affect CVR. This review explores the biological mechanisms underpinning these brain-behaviour associations, highlights evident gaps in the literature, and identifies the risk factors that could be managed to preserve CVR in an effort to prevent dementia.</p> |
| first_indexed | 2024-03-07T07:49:13Z |
| format | Journal article |
| id | oxford-uuid:e92cb9e9-9c97-4da0-bc9d-c8e9dc4e9386 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:49:13Z |
| publishDate | 2023 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:e92cb9e9-9c97-4da0-bc9d-c8e9dc4e93862023-07-03T10:31:14ZA systematic review of the association between dementia risk factors and cerebrovascular reactivityJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e92cb9e9-9c97-4da0-bc9d-c8e9dc4e9386EnglishSymplectic ElementsElsevier 2023Wang, CReid, GMackay, CEHayes, GBulte, DPSuri, S<p>Cumulative evidence suggests that impaired cerebrovascular reactivity (CVR), a regulatory response critical for maintaining neuronal health, is amongst the earliest pathological changes in dementia. However, we know little about how CVR is affected by dementia risk, prior to disease onset. Understanding this relationship would improve our knowledge of disease pathways and help inform preventative interventions. This systematic review investigates 59 studies examining how CVR (measured by magnetic resonance imaging) is affected by modifiable, non-modifiable, and clinical risk factors for dementia. We report that non-modifiable risk (older age and apolipoprotein ε4), some modifiable factors (diabetes, traumatic brain injury, hypertension) and some clinical factors (stroke, carotid artery occlusion, stenosis) were consistently associated with reduced CVR. We also note a lack of conclusive evidence on how other behavioural factors such as physical inactivity, obesity, or depression, affect CVR. This review explores the biological mechanisms underpinning these brain-behaviour associations, highlights evident gaps in the literature, and identifies the risk factors that could be managed to preserve CVR in an effort to prevent dementia.</p> |
| spellingShingle | Wang, C Reid, G Mackay, CE Hayes, G Bulte, DP Suri, S A systematic review of the association between dementia risk factors and cerebrovascular reactivity |
| title | A systematic review of the association between dementia risk factors and cerebrovascular reactivity |
| title_full | A systematic review of the association between dementia risk factors and cerebrovascular reactivity |
| title_fullStr | A systematic review of the association between dementia risk factors and cerebrovascular reactivity |
| title_full_unstemmed | A systematic review of the association between dementia risk factors and cerebrovascular reactivity |
| title_short | A systematic review of the association between dementia risk factors and cerebrovascular reactivity |
| title_sort | systematic review of the association between dementia risk factors and cerebrovascular reactivity |
| work_keys_str_mv | AT wangc asystematicreviewoftheassociationbetweendementiariskfactorsandcerebrovascularreactivity AT reidg asystematicreviewoftheassociationbetweendementiariskfactorsandcerebrovascularreactivity AT mackayce asystematicreviewoftheassociationbetweendementiariskfactorsandcerebrovascularreactivity AT hayesg asystematicreviewoftheassociationbetweendementiariskfactorsandcerebrovascularreactivity AT bultedp asystematicreviewoftheassociationbetweendementiariskfactorsandcerebrovascularreactivity AT suris asystematicreviewoftheassociationbetweendementiariskfactorsandcerebrovascularreactivity AT wangc systematicreviewoftheassociationbetweendementiariskfactorsandcerebrovascularreactivity AT reidg systematicreviewoftheassociationbetweendementiariskfactorsandcerebrovascularreactivity AT mackayce systematicreviewoftheassociationbetweendementiariskfactorsandcerebrovascularreactivity AT hayesg systematicreviewoftheassociationbetweendementiariskfactorsandcerebrovascularreactivity AT bultedp systematicreviewoftheassociationbetweendementiariskfactorsandcerebrovascularreactivity AT suris systematicreviewoftheassociationbetweendementiariskfactorsandcerebrovascularreactivity |