A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.

A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus.

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease more prevalent in people of African and Asian origin than Caucasian origin. FcgammaRIIb is an inhibitory Fc receptor with a critical role in immune regulation. Mouse data suggest that FcgammaRIIb deficiency increases susceptibili...

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Bibliographic Details
Main Authors:	Willcocks, L, Carr, E, Niederer, H, Rayner, T, Williams, T, Yang, W, Scott, J, Urban, B, Peshu, N, Vyse, T, Lau, Y, Lyons, P, Smith, K
Format:	Journal article
Language:	English
Published:	2010

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