Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology

<p>Pathological loss-of-function mutations in cyclin-dependent kinase-like 5 (<em>CDKL5</em>) cause CDKL5 deficiency disorder (CDD), a rare and severe neurodevelopmental disorder associated with severe and medically refractory early-life epilepsy, motor, cognitive, visual, and auto...

书目详细资料
Main Authors:	Castano, A, Silvestre, M, Wells, CI, Sanderson, JL, Ferrer, CA, Ong, HW, Lang, Y, Richardson, W, Silvaroli, JA, Bashore, FM, Smith, JL, Genereux, IM, Dempster, K, Drewry, DH, Pabla, NS, Bullock, AN, Benke, TA, Ultanir, S, Axtman, AD
格式:	Journal article
语言:	English
出版:	eLife Sciences Publications 2023

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