STUDIES ON THE EXCHANGE OF VALINE-OXYGEN DURING THE BIOSYNTHESIS OF DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE
Incorporation of [4-2H6,18O2]-valine into δ-(L)-α-aminoadipoyl)-L-cysteinyl-D-valine (ACV), by intact cells of Cephalosporium acremonium, demonstrated the intracellular exchange of one and both valine oxygen atoms. Incubation of [18O2]-valine with the purified ACV synthetase from C. acremonium gave...
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| Fformat: | Journal article |
| Iaith: | English |
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1992
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| _version_ | 1826302751449022464 |
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| author | Baldwin, J Adlington, R Bird, J Field, R Ocallaghan, N Schofield, C |
| author_facet | Baldwin, J Adlington, R Bird, J Field, R Ocallaghan, N Schofield, C |
| author_sort | Baldwin, J |
| collection | OXFORD |
| description | Incorporation of [4-2H6,18O2]-valine into δ-(L)-α-aminoadipoyl)-L-cysteinyl-D-valine (ACV), by intact cells of Cephalosporium acremonium, demonstrated the intracellular exchange of one and both valine oxygen atoms. Incubation of [18O2]-valine with the purified ACV synthetase from C. acremonium gave exclusive incorporation of a single 18O label into ACV, consistent witheffectively non-reversible formation of a covalent valinoyl-ACV synthetase intermediate under in vitro conditions. © 1992. |
| first_indexed | 2024-03-07T05:52:17Z |
| format | Journal article |
| id | oxford-uuid:e94d4da9-1e79-46ff-82ba-19db925e94e6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:52:17Z |
| publishDate | 1992 |
| record_format | dspace |
| spelling | oxford-uuid:e94d4da9-1e79-46ff-82ba-19db925e94e62022-03-27T10:53:14ZSTUDIES ON THE EXCHANGE OF VALINE-OXYGEN DURING THE BIOSYNTHESIS OF DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINEJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e94d4da9-1e79-46ff-82ba-19db925e94e6EnglishSymplectic Elements at Oxford1992Baldwin, JAdlington, RBird, JField, ROcallaghan, NSchofield, CIncorporation of [4-2H6,18O2]-valine into δ-(L)-α-aminoadipoyl)-L-cysteinyl-D-valine (ACV), by intact cells of Cephalosporium acremonium, demonstrated the intracellular exchange of one and both valine oxygen atoms. Incubation of [18O2]-valine with the purified ACV synthetase from C. acremonium gave exclusive incorporation of a single 18O label into ACV, consistent witheffectively non-reversible formation of a covalent valinoyl-ACV synthetase intermediate under in vitro conditions. © 1992. |
| spellingShingle | Baldwin, J Adlington, R Bird, J Field, R Ocallaghan, N Schofield, C STUDIES ON THE EXCHANGE OF VALINE-OXYGEN DURING THE BIOSYNTHESIS OF DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE |
| title | STUDIES ON THE EXCHANGE OF VALINE-OXYGEN DURING THE BIOSYNTHESIS OF DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE |
| title_full | STUDIES ON THE EXCHANGE OF VALINE-OXYGEN DURING THE BIOSYNTHESIS OF DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE |
| title_fullStr | STUDIES ON THE EXCHANGE OF VALINE-OXYGEN DURING THE BIOSYNTHESIS OF DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE |
| title_full_unstemmed | STUDIES ON THE EXCHANGE OF VALINE-OXYGEN DURING THE BIOSYNTHESIS OF DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE |
| title_short | STUDIES ON THE EXCHANGE OF VALINE-OXYGEN DURING THE BIOSYNTHESIS OF DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE |
| title_sort | studies on the exchange of valine oxygen during the biosynthesis of delta l alpha aminoadipoyl l cysteinyl d valine |
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