Importance of collection tube during clinical studies of oseltamivir.

Ex vivo conversion of the anti-influenza drug oseltamivir to its active metabolite can be inhibited by the esterase inhibitor dichlorvos or by using commercial fluoride-oxalate tubes. Oseltamivir and its active metabolite remain intact in plasma samples during a proposed virus heat inactivation step...

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Hlavní autoři: Lindegardh, N, Davies, G, Hien, T, Farrar, J, Singhasivanon, P, Day, N, White, N
Médium: Journal article
Jazyk:English
Vydáno: 2007