Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.

BH4 (tetrahydrobiopterin) supplementation improves endothelial function in models of vascular disease by maintaining eNOS (endothelial nitric oxide synthase) coupling and NO (nitric oxide) bioavailability. However, the cellular mechanisms through which enhanced endothelial function leads to reduced...

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Bibliographic Details
Main Authors:	Schmidt, T, McNeill, E, Douglas, G, Crabtree, M, Hale, AB, Khoo, J, O'Neill, C, Cheng, A, Channon, K, Alp, N
Format:	Journal article
Language:	English
Published:	2010

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