RGMs: Structural insights, molecular regulation, and downstream signaling
Although originally discovered as neuronal growth cone-collapsing factors, repulsive guidance molecules (RGMs) are now known as key players in many fundamental processes, such as cell migration, differentiation, iron homeostasis, and apoptosis, during the development and homeostasis of many tissues...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Cell Press
2016
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| _version_ | 1797101503187517440 |
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| author | Siebold, C Yamashita, T Monnier, P Mueller, B Pasterkamp, R |
| author_facet | Siebold, C Yamashita, T Monnier, P Mueller, B Pasterkamp, R |
| author_sort | Siebold, C |
| collection | OXFORD |
| description | Although originally discovered as neuronal growth cone-collapsing factors, repulsive guidance molecules (RGMs) are now known as key players in many fundamental processes, such as cell migration, differentiation, iron homeostasis, and apoptosis, during the development and homeostasis of many tissues and organs, including the nervous, skeletal, and immune systems. Furthermore, three RGMs (RGMa, RGMb/DRAGON, and RGMc/hemojuvelin) have been linked to the pathogenesis of various disorders ranging from multiple sclerosis (MS) to cancer and juvenile hemochromatosis (JHH). While the molecular details of these (patho)biological effects and signaling modes have long remained unknown, recent studies unveil several exciting and novel aspects of RGM processing, ligand-receptor interactions, and downstream signaling. In this review, we highlight recent advances in the mechanisms-of-action and function of RGM proteins. |
| first_indexed | 2024-03-07T05:52:54Z |
| format | Journal article |
| id | oxford-uuid:e980a89e-c69b-46c4-931e-8f556e7d4546 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:52:54Z |
| publishDate | 2016 |
| publisher | Cell Press |
| record_format | dspace |
| spelling | oxford-uuid:e980a89e-c69b-46c4-931e-8f556e7d45462022-03-27T10:54:52ZRGMs: Structural insights, molecular regulation, and downstream signalingJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e980a89e-c69b-46c4-931e-8f556e7d4546EnglishSymplectic Elements at OxfordCell Press2016Siebold, CYamashita, TMonnier, PMueller, BPasterkamp, RAlthough originally discovered as neuronal growth cone-collapsing factors, repulsive guidance molecules (RGMs) are now known as key players in many fundamental processes, such as cell migration, differentiation, iron homeostasis, and apoptosis, during the development and homeostasis of many tissues and organs, including the nervous, skeletal, and immune systems. Furthermore, three RGMs (RGMa, RGMb/DRAGON, and RGMc/hemojuvelin) have been linked to the pathogenesis of various disorders ranging from multiple sclerosis (MS) to cancer and juvenile hemochromatosis (JHH). While the molecular details of these (patho)biological effects and signaling modes have long remained unknown, recent studies unveil several exciting and novel aspects of RGM processing, ligand-receptor interactions, and downstream signaling. In this review, we highlight recent advances in the mechanisms-of-action and function of RGM proteins. |
| spellingShingle | Siebold, C Yamashita, T Monnier, P Mueller, B Pasterkamp, R RGMs: Structural insights, molecular regulation, and downstream signaling |
| title | RGMs: Structural insights, molecular regulation, and downstream signaling |
| title_full | RGMs: Structural insights, molecular regulation, and downstream signaling |
| title_fullStr | RGMs: Structural insights, molecular regulation, and downstream signaling |
| title_full_unstemmed | RGMs: Structural insights, molecular regulation, and downstream signaling |
| title_short | RGMs: Structural insights, molecular regulation, and downstream signaling |
| title_sort | rgms structural insights molecular regulation and downstream signaling |
| work_keys_str_mv | AT sieboldc rgmsstructuralinsightsmolecularregulationanddownstreamsignaling AT yamashitat rgmsstructuralinsightsmolecularregulationanddownstreamsignaling AT monnierp rgmsstructuralinsightsmolecularregulationanddownstreamsignaling AT muellerb rgmsstructuralinsightsmolecularregulationanddownstreamsignaling AT pasterkampr rgmsstructuralinsightsmolecularregulationanddownstreamsignaling |