Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.
The human hemopoietic progenitor hierarchy producing lymphoid and granulocytic-monocytic (myeloid) lineages is unclear. Multiple progenitor populations produce lymphoid and myeloid cells, but remain incompletely characterized. Here, we demonstrated cord blood lympho-myeloid containing progenitor pop...
| Автори: | , , , , , , , , , , , , , , , , , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
Nature Publishing Group
2017
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| _version_ | 1826302804181909504 |
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| author | Karamitros, D Stoilova, B Aboukhalil, Z Hamey, F Reinisch, A Samitsch, M Quek, L Otto, G Repapi, E Doondeea, J Usukhbayar, B Calvo, J Taylor, S Goardon, N Six, E Pflumio, F Porcher, C Majeti, R Göttgens, B Vyas, P |
| author_facet | Karamitros, D Stoilova, B Aboukhalil, Z Hamey, F Reinisch, A Samitsch, M Quek, L Otto, G Repapi, E Doondeea, J Usukhbayar, B Calvo, J Taylor, S Goardon, N Six, E Pflumio, F Porcher, C Majeti, R Göttgens, B Vyas, P |
| author_sort | Karamitros, D |
| collection | OXFORD |
| description | The human hemopoietic progenitor hierarchy producing lymphoid and granulocytic-monocytic (myeloid) lineages is unclear. Multiple progenitor populations produce lymphoid and myeloid cells, but remain incompletely characterized. Here, we demonstrated cord blood lympho-myeloid containing progenitor populations - the lymphoid-primed multi-potential progenitor (LMPP), granulocyte-macrophage progenitor (GMP) and multi-lymphoid progenitor (MLP) - were functionally and transcriptionally distinct and heterogeneous at the clonal level, with progenitors of many different functional potentials present. Though most progenitors had uni-lineage myeloid or lymphoid potential, bi- and rarer multi-lineage progenitors occurred in LMPP, GMP and MLP. This, coupled with single cell expression analyses, suggested a continuum of progenitors execute lymphoid and myeloid differentiation rather than only uni-lineage progenitors being present downstream of stem cells. |
| first_indexed | 2024-03-07T05:52:59Z |
| format | Journal article |
| id | oxford-uuid:e98946bc-6687-40e7-8360-be6887d1c5a5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:52:59Z |
| publishDate | 2017 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:e98946bc-6687-40e7-8360-be6887d1c5a52022-03-27T10:55:08ZSingle-cell analysis reveals the continuum of human lympho-myeloid progenitor cells.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e98946bc-6687-40e7-8360-be6887d1c5a5EnglishSymplectic Elements at OxfordNature Publishing Group2017Karamitros, DStoilova, BAboukhalil, ZHamey, FReinisch, ASamitsch, MQuek, LOtto, GRepapi, EDoondeea, JUsukhbayar, BCalvo, JTaylor, SGoardon, NSix, EPflumio, FPorcher, CMajeti, RGöttgens, BVyas, PThe human hemopoietic progenitor hierarchy producing lymphoid and granulocytic-monocytic (myeloid) lineages is unclear. Multiple progenitor populations produce lymphoid and myeloid cells, but remain incompletely characterized. Here, we demonstrated cord blood lympho-myeloid containing progenitor populations - the lymphoid-primed multi-potential progenitor (LMPP), granulocyte-macrophage progenitor (GMP) and multi-lymphoid progenitor (MLP) - were functionally and transcriptionally distinct and heterogeneous at the clonal level, with progenitors of many different functional potentials present. Though most progenitors had uni-lineage myeloid or lymphoid potential, bi- and rarer multi-lineage progenitors occurred in LMPP, GMP and MLP. This, coupled with single cell expression analyses, suggested a continuum of progenitors execute lymphoid and myeloid differentiation rather than only uni-lineage progenitors being present downstream of stem cells. |
| spellingShingle | Karamitros, D Stoilova, B Aboukhalil, Z Hamey, F Reinisch, A Samitsch, M Quek, L Otto, G Repapi, E Doondeea, J Usukhbayar, B Calvo, J Taylor, S Goardon, N Six, E Pflumio, F Porcher, C Majeti, R Göttgens, B Vyas, P Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells. |
| title | Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells. |
| title_full | Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells. |
| title_fullStr | Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells. |
| title_full_unstemmed | Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells. |
| title_short | Single-cell analysis reveals the continuum of human lympho-myeloid progenitor cells. |
| title_sort | single cell analysis reveals the continuum of human lympho myeloid progenitor cells |
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