IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism.

IFN-gamma protects short-term ovarian carcinoma cell lines from CTL lysis via a CD94/NKG2A-dependent mechanism.

IFN-gamma regulates the immunogenicity of target cells by increasing their expression of HLA class I molecules. This facilitates the T cell receptor-mediated recognition by CD8(+) T cells but decreases target cell sensitivity to lysis by NK cells due to engagement of inhibitory NK receptors. In this...

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Bibliographic Details
Main Authors: Malmberg, K, Levitsky, V, Norell, H, de Matos, C, Carlsten, M, Schedvins, K, Rabbani, H, Moretta, A, Söderström, K, Levitskaya, J, Kiessling, R
Format: Journal article
Language:English
Published: 2002

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