The use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin II
The total synthesis of phytotoxic nonenolide herbarumin II (1) has been achieved by implementation of butane diacetal (BDA)-desymmetrised glycolate building blocks. Three of the four stereogenic centres present in the key coupling fragments were generated from both enantiomeric forms of the BDA buil...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
2003
|
| _version_ | 1797101563481686016 |
|---|---|
| author | Diez, E Dixon, D Ley, S Polara, A Rodriguez, F |
| author_facet | Diez, E Dixon, D Ley, S Polara, A Rodriguez, F |
| author_sort | Diez, E |
| collection | OXFORD |
| description | The total synthesis of phytotoxic nonenolide herbarumin II (1) has been achieved by implementation of butane diacetal (BDA)-desymmetrised glycolate building blocks. Three of the four stereogenic centres present in the key coupling fragments were generated from both enantiomeric forms of the BDA building block in highly diastereoselective alkylation and aldol reactions. |
| first_indexed | 2024-03-07T05:53:37Z |
| format | Journal article |
| id | oxford-uuid:e9c3c245-e4e1-4f07-abdf-92a79175f7cd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:53:37Z |
| publishDate | 2003 |
| record_format | dspace |
| spelling | oxford-uuid:e9c3c245-e4e1-4f07-abdf-92a79175f7cd2022-03-27T10:56:36ZThe use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin IIJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e9c3c245-e4e1-4f07-abdf-92a79175f7cdEnglishSymplectic Elements at Oxford2003Diez, EDixon, DLey, SPolara, ARodriguez, FThe total synthesis of phytotoxic nonenolide herbarumin II (1) has been achieved by implementation of butane diacetal (BDA)-desymmetrised glycolate building blocks. Three of the four stereogenic centres present in the key coupling fragments were generated from both enantiomeric forms of the BDA building block in highly diastereoselective alkylation and aldol reactions. |
| spellingShingle | Diez, E Dixon, D Ley, S Polara, A Rodriguez, F The use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin II |
| title | The use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin II |
| title_full | The use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin II |
| title_fullStr | The use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin II |
| title_full_unstemmed | The use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin II |
| title_short | The use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin II |
| title_sort | use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin ii |
| work_keys_str_mv | AT dieze theuseofbutanediacetalsofglycolicacidasprecursorsforthesynthesisofthephytotoxiccalmodulininhibitorherbaruminii AT dixond theuseofbutanediacetalsofglycolicacidasprecursorsforthesynthesisofthephytotoxiccalmodulininhibitorherbaruminii AT leys theuseofbutanediacetalsofglycolicacidasprecursorsforthesynthesisofthephytotoxiccalmodulininhibitorherbaruminii AT polaraa theuseofbutanediacetalsofglycolicacidasprecursorsforthesynthesisofthephytotoxiccalmodulininhibitorherbaruminii AT rodriguezf theuseofbutanediacetalsofglycolicacidasprecursorsforthesynthesisofthephytotoxiccalmodulininhibitorherbaruminii AT dieze useofbutanediacetalsofglycolicacidasprecursorsforthesynthesisofthephytotoxiccalmodulininhibitorherbaruminii AT dixond useofbutanediacetalsofglycolicacidasprecursorsforthesynthesisofthephytotoxiccalmodulininhibitorherbaruminii AT leys useofbutanediacetalsofglycolicacidasprecursorsforthesynthesisofthephytotoxiccalmodulininhibitorherbaruminii AT polaraa useofbutanediacetalsofglycolicacidasprecursorsforthesynthesisofthephytotoxiccalmodulininhibitorherbaruminii AT rodriguezf useofbutanediacetalsofglycolicacidasprecursorsforthesynthesisofthephytotoxiccalmodulininhibitorherbaruminii |