RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.

RASSF1A-LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2.

Genomic instability is a key hallmark of cancer leading to tumour heterogeneity and therapeutic resistance. BRCA2 has a fundamental role in error-free DNA repair but also sustains genome integrity by promoting RAD51 nucleofilament formation at stalled replication forks. CDK2 phosphorylates BRCA2 (pS...

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Bibliographic Details
Main Authors:	Pefani, D, Latusek, R, Pires, I, Grawenda, A, Yee, K, Hamilton, G, van der Weyden, L, Esashi, F, Hammond, E, O'Neill, E
Format:	Journal article
Language:	English
Published:	2014

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