Biaryl acids: novel non-nucleoside inhibitors of HIV reverse transcriptase types 1 and 2.
A series of biaryl acids has been found to show micromolar inhibition of the HIV reverse transcriptase (RT) from types 1 and 2 with IC50S in the micromolar range. The series was discovered by consideration of the polymerase active site and sub-structure searching of the company compound collection....
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Bibliographic Details
| Main Authors: |
Milton, J,
Slater, M,
Bird, A,
Spinks, D,
Scott, G,
Price, C,
Downing, S,
Green, D,
Madar, S,
Bethell, R,
Stammers, D |
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| Format: | Journal article
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| Language: | English |
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| Published: |
1998
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