Carbon-carbon bond formation via rhodium-catalysed C-S activation processes
In the following thesis, new methodologies towards harnessing C-S activation processes are documented. These methods utilise rhodium catalysis and are focused on the activation of aryl methyl sulfides.<br/> Chapter 1 provides an overview of the development of metal-catalysed C-S activation...
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| Other Authors: | |
| Format: | Thesis |
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2015
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| _version_ | 1826310556416475136 |
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| author | Arambasic, M |
| author2 | Willis, M |
| author_facet | Willis, M Arambasic, M |
| author_sort | Arambasic, M |
| collection | OXFORD |
| description | In the following thesis, new methodologies towards harnessing C-S activation processes are documented. These methods utilise rhodium catalysis and are focused on the activation of aryl methyl sulfides.<br/> Chapter 1 provides an overview of the development of metal-catalysed C-S activation chemistry, with a focus on the catalytic systems, reagents and starting materials used to facilitate various C-C bond forming transformations.<br/> Chapter 2 describes a novel rhodium-catalysed cross-coupling reaction of aryl and alkyl terminal alkynes with simple aryl sulfides. This resulted in a Sonogashira-type transformation which exhibited orthogonality with traditional palladium catalysed Sonogashira chemistry.<br/> Chapter 3 documents a new catalytic system which allowed for the practical and efficient alkyne carbothiolation reactions of ketone-baring methyl sulfides. The carbothiolation products can be conveniently utilised in a one-pot three-component reaction to form highly substituted isoquinolines.<br/> Chapter 4 discusses the potential for future work.<br/> Chapter 5 presents the experimental data. |
| first_indexed | 2024-03-07T07:53:42Z |
| format | Thesis |
| id | oxford-uuid:e9e29a73-e637-4844-9a37-58b5ae4a3f99 |
| institution | University of Oxford |
| last_indexed | 2024-03-07T07:53:42Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | oxford-uuid:e9e29a73-e637-4844-9a37-58b5ae4a3f992023-08-01T10:20:57ZCarbon-carbon bond formation via rhodium-catalysed C-S activation processesThesishttp://purl.org/coar/resource_type/c_db06uuid:e9e29a73-e637-4844-9a37-58b5ae4a3f99ORA Deposit2015Arambasic, MWillis, MIn the following thesis, new methodologies towards harnessing C-S activation processes are documented. These methods utilise rhodium catalysis and are focused on the activation of aryl methyl sulfides.<br/> Chapter 1 provides an overview of the development of metal-catalysed C-S activation chemistry, with a focus on the catalytic systems, reagents and starting materials used to facilitate various C-C bond forming transformations.<br/> Chapter 2 describes a novel rhodium-catalysed cross-coupling reaction of aryl and alkyl terminal alkynes with simple aryl sulfides. This resulted in a Sonogashira-type transformation which exhibited orthogonality with traditional palladium catalysed Sonogashira chemistry.<br/> Chapter 3 documents a new catalytic system which allowed for the practical and efficient alkyne carbothiolation reactions of ketone-baring methyl sulfides. The carbothiolation products can be conveniently utilised in a one-pot three-component reaction to form highly substituted isoquinolines.<br/> Chapter 4 discusses the potential for future work.<br/> Chapter 5 presents the experimental data. |
| spellingShingle | Arambasic, M Carbon-carbon bond formation via rhodium-catalysed C-S activation processes |
| title | Carbon-carbon bond formation via rhodium-catalysed C-S activation processes |
| title_full | Carbon-carbon bond formation via rhodium-catalysed C-S activation processes |
| title_fullStr | Carbon-carbon bond formation via rhodium-catalysed C-S activation processes |
| title_full_unstemmed | Carbon-carbon bond formation via rhodium-catalysed C-S activation processes |
| title_short | Carbon-carbon bond formation via rhodium-catalysed C-S activation processes |
| title_sort | carbon carbon bond formation via rhodium catalysed c s activation processes |
| work_keys_str_mv | AT arambasicm carboncarbonbondformationviarhodiumcatalysedcsactivationprocesses |