A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.
To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC case...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797101597978787840 |
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| author | Tomlinson, I Webb, E Carvajal-Carmona, L Broderick, P Howarth, K Pittman, A Spain, S Lubbe, S Walther, A Sullivan, K Jaeger, E Fielding, S Rowan, A Vijayakrishnan, J Domingo, E Chandler, I Kemp, Z Qureshi, M Farrington, S Tenesa, A Prendergast, J Barnetson, R Penegar, S Barclay, E Wood, W |
| author_facet | Tomlinson, I Webb, E Carvajal-Carmona, L Broderick, P Howarth, K Pittman, A Spain, S Lubbe, S Walther, A Sullivan, K Jaeger, E Fielding, S Rowan, A Vijayakrishnan, J Domingo, E Chandler, I Kemp, Z Qureshi, M Farrington, S Tenesa, A Prendergast, J Barnetson, R Penegar, S Barclay, E Wood, W |
| author_sort | Tomlinson, I |
| collection | OXFORD |
| description | To identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10(-4) in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition. |
| first_indexed | 2024-03-07T05:54:05Z |
| format | Journal article |
| id | oxford-uuid:e9e89748-67a7-456a-bf4f-79444b3ebdeb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:54:05Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:e9e89748-67a7-456a-bf4f-79444b3ebdeb2022-03-27T10:57:54ZA genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:e9e89748-67a7-456a-bf4f-79444b3ebdebEnglishSymplectic Elements at Oxford2008Tomlinson, IWebb, ECarvajal-Carmona, LBroderick, PHowarth, KPittman, ASpain, SLubbe, SWalther, ASullivan, KJaeger, EFielding, SRowan, AVijayakrishnan, JDomingo, EChandler, IKemp, ZQureshi, MFarrington, STenesa, APrendergast, JBarnetson, RPenegar, SBarclay, EWood, WTo identify colorectal cancer (CRC) susceptibility alleles, we conducted a genome-wide association study. In phase 1, we genotyped 550,163 tagSNPs in 940 familial colorectal tumor cases (627 CRC, 313 high-risk adenoma) and 965 controls. In phase 2, we genotyped 42,708 selected SNPs in 2,873 CRC cases and 2,871 controls. In phase 3, we evaluated 11 SNPs showing association at P < 10(-4) in a joint analysis of phases 1 and 2 in 4,287 CRC cases and 3,743 controls. Two SNPs were taken forward to phase 4 genotyping (10,731 CRC cases and 10,961 controls from eight centers). In addition to the previously reported 8q24, 15q13 and 18q21 CRC risk loci, we identified two previously unreported associations: rs10795668, located at 10p14 (P = 2.5 x 10(-13) overall; P = 6.9 x 10(-12) replication), and rs16892766, at 8q23.3 (P = 3.3 x 10(-18) overall; P = 9.6 x 10(-17) replication), which tags a plausible causative gene, EIF3H. These data provide further evidence for the 'common-disease common-variant' model of CRC predisposition. |
| spellingShingle | Tomlinson, I Webb, E Carvajal-Carmona, L Broderick, P Howarth, K Pittman, A Spain, S Lubbe, S Walther, A Sullivan, K Jaeger, E Fielding, S Rowan, A Vijayakrishnan, J Domingo, E Chandler, I Kemp, Z Qureshi, M Farrington, S Tenesa, A Prendergast, J Barnetson, R Penegar, S Barclay, E Wood, W A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. |
| title | A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. |
| title_full | A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. |
| title_fullStr | A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. |
| title_full_unstemmed | A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. |
| title_short | A genome-wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23.3. |
| title_sort | genome wide association study identifies colorectal cancer susceptibility loci on chromosomes 10p14 and 8q23 3 |
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