Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.

BACKGROUND AND PURPOSE: 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4 ) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH4 restores vascular function in patients. Unfortunately, oral BH4 has limited efficacy. Therefore, orally bioavai...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Hussein, D, Starr, A, Heikal, L, McNeill, E, Channon, K, Brown, P, Sutton, B, McDonnell, J, Nandi, M
التنسيق:	Journal article
اللغة:	English
منشور في:	Wiley 2015

مواد مشابهة

Overexpression of GTP cyclohydrolase 1 feedback regulatory protein is protective in a murine model of septic shock.
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GTP cyclohydrolase I expression, protein, and activity determine intracellular tetrahydrobiopterin levels, independent of GTP cyclohydrolase feedback regulatory protein expression.
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Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
حسب: Chuaiphichai, S, وآخرون
منشور في: (2014)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
حسب: Chuaiphichai, S, وآخرون
منشور في: (2014)

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.
حسب: Ryan, B, وآخرون
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GTP cyclohydrolase II structure and mechanism.
حسب: Ren, J, وآخرون
منشور في: (2005)

Endothelial GTP cyclohydrolase and tetrahydrobiopterin regulate gestational blood pressure, uteroplacental remodeling and fetal growth
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GTP cyclohydrolase I deficiency results in oxidative stress and pulmonary hypertension
حسب: Khoo, J, وآخرون
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303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
حسب: Chuaiphichai, S, وآخرون
منشور في: (2014)

GTP cyclohydrolase as a novel mechanism for tumour growth
حسب: Chen, L, وآخرون
منشور في: (2015)

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Decreased Cardiac Allograft Rejection in Mice Over-Expressing Human GTP Cyclohydrolase I.
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منشور في: (2009)

Cardiomyocyte-Targeted Overexpression of GTP Cyclohydrolase-1 Increases Myocyte Lusitropy and Reduces Superoxide Production
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Endothelial-targeted GTP cyclohydrolase I overexpression prevents blood pressure progression in mineralocorticoid hypertension
حسب: Du, Y, وآخرون
منشور في: (2005)

Endothelial-targeted GTP cyclohydrolase I overexpression prevents blood pressure progression in mineralocorticoid hypertension\
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Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1.
حسب: Wang, W, وآخرون
منشور في: (2008)

Endothelium-targeted transgenic GTP-cyclohydrolase I overexpression inhibits neointima formation in mouse carotid artery.
حسب: Liao, S, وآخرون
منشور في: (2007)

Endothelial-specific GTP cyclohydrolase I overexpression prevents blood pressure progression in salt-sensitive hypertension
حسب: Chen, A, وآخرون
منشور في: (2005)

Control of GTP Cyclohydrolase I Activity during Aggregation of Dictyostelium discoideum
حسب: Ziegler Irmgard, وآخرون
منشور في: (1995-08-01)

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
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Functional Studies on the Promoter Region of the Human GTP Cyclohydrolase I Gene
حسب: Gütlich Markus, وآخرون
منشور في: (1995-08-01)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
حسب: Carnicer, R, وآخرون
منشور في: (2012)

Cardiomyocyte GTP cyclohydrolase 1 and tetrahydrobiopterin increase NOS1 activity and accelerate myocardial relaxation
حسب: Carnicer, R, وآخرون
منشور في: (2012)

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin.
حسب: Adlam, D, وآخرون
منشور في: (2012)

Cardiomyocyte-targeted overexpression of GTP cyclohydrolase-1 increases nNOS activity and hastens myocardial relaxation
حسب: Carnicer, R, وآخرون
منشور في: (2011)

Endothelium-specific GTP cyclohydrolase I overexpression accelerates refractory wound healing by suppressing oxidative stress in diabetes.
حسب: Tie, L, وآخرون
منشور في: (2009)

Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin
حسب: Adlam, D, وآخرون
منشور في: (2012)

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
حسب: Alp, N, وآخرون
منشور في: (2003)

Endothelium-targeted GTP cyclohydrolase I overexpression inhibits wire injury-induced restenosis in mouse carotid artery
حسب: Chen, A, وآخرون
منشور في: (2005)

Nitric oxide bioactivity in ApoE -/- mice is maintained by increased endothelial tetrahydrobiopterin synthesis via targeted GTP cyclohydrolase-1 over-expression
حسب: Alp, N, وآخرون
منشور في: (2003)

Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension.
حسب: Du, Y, وآخرون
منشور في: (2008)

Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice.
حسب: Alp, N, وآخرون
منشور في: (2004)

Systemic adenovirus-mediated gene transfer of human GTP cyclohydrolase-1 increases liver, plasma and aortic tetrahydrobiopterin levels in mice
حسب: Alp, N, وآخرون
منشور في: (2002)

Genetic variation in GCH1, encoding GTP-cyclohydrolase 1, regulates biopterin levels and endothelial function in atherosclerosis
حسب: Van, A, وآخرون
منشور في: (2008)

GTP Cyclohydrolase/BH4 Pathway Protects EPC Function via Suppressing Oxidative Stress and Thrombospondin-1 in Salt-Sensitive Hypertension
حسب: Xie, H, وآخرون
منشور في: (2009)

Nitrosative stress induced by homocysteine thiolactone drives vascular cognitive impairments via GTP cyclohydrolase 1 S-nitrosylation in vivo
حسب: Ya-Ling Yin, وآخرون
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Serotonergic system in vivo with [11C]DASB PET scans in GTP-cyclohydrolase deficient dopa-responsive dystonia patients
حسب: Elze R. Timmers, وآخرون
منشور في: (2022-04-01)

Tetrahydrobiopterin-dependent preservation of nitric oxide-mediated endothelial function in diabetes by targeted transgenic GTP-cyclohydrolase I overexpression.
حسب: Alp, N, وآخرون
منشور في: (2003)