Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.

Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches.

BACKGROUND AND PURPOSE: 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH4 ) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH4 restores vascular function in patients. Unfortunately, oral BH4 has limited efficacy. Therefore, orally bioavai...

Полное описание

Библиографические подробности
Главные авторы:	Hussein, D, Starr, A, Heikal, L, McNeill, E, Channon, K, Brown, P, Sutton, B, McDonnell, J, Nandi, M
Формат:	Journal article
Язык:	English
Опубликовано:	Wiley 2015

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