A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.

A mouse model for the metabolic effects of the human fat mass and obesity associated FTO gene.

Human FTO gene variants are associated with body mass index and type 2 diabetes. Because the obesity-associated SNPs are intronic, it is unclear whether changes in FTO expression or splicing are the cause of obesity or if regulatory elements within intron 1 influence upstream or downstream genes. We...

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Dettagli Bibliografici
Autori principali:	Church, C, Lee, S, Bagg, E, McTaggart, J, Deacon, R, Gerken, T, Lee, A, Moir, L, Mecinovic, J, Quwailid, M, Schofield, C, Ashcroft, F, Cox, R
Natura:	Journal article
Lingua:	English
Pubblicazione:	Public Library of Science 2009

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