Nuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis.
PURPOSE: We determined the role of factor inhibiting hypoxia-inducible factor-1 in prostate cancer specimens. MATERIALS AND METHODS: A tissue microarray of 152 prostate cancers was constructed and stained for factor inhibiting hypoxia-inducible factor-1, hypoxia-inducible factor-1α and 2α, and gluc...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2011
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| _version_ | 1797101634627567616 |
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| author | Shaida, N Chan, P Turley, H Jones, C Kanga, S Ritchie, R Malone, P Harris, A Fox, S |
| author_facet | Shaida, N Chan, P Turley, H Jones, C Kanga, S Ritchie, R Malone, P Harris, A Fox, S |
| author_sort | Shaida, N |
| collection | OXFORD |
| description | PURPOSE: We determined the role of factor inhibiting hypoxia-inducible factor-1 in prostate cancer specimens. MATERIALS AND METHODS: A tissue microarray of 152 prostate cancers was constructed and stained for factor inhibiting hypoxia-inducible factor-1, hypoxia-inducible factor-1α and 2α, and glucose transporter 1 as a prototypical downstream target of hypoxia-inducible factor-1α. Correlation analysis was done between these variables, and between factor inhibiting hypoxia-inducible factor-1, and clinical and pathological variables, including prostate specific antigen as a surrogate of recurrence. RESULTS: Factor inhibiting hypoxia-inducible factor-1 was expressed in the cytoplasm and/or the nucleus in 86.5% of tumors, including exclusive cytoplasmic expression in 51.3% and exclusive nuclear expression in 5.3%. Any nuclear and exclusive expression of factor inhibiting hypoxia-inducible factor was associated with poor prognosis on univariate analysis (p = 0.007 and 0.042, respectively). On multivariate analysis men with nuclear expression in tumors were twice as likely to experience recurrence (p = 0.034). CONCLUSIONS: Factor inhibiting hypoxia-inducible factor-1 is widely expressed in prostate tumors. Its differential subcellular expression suggests that regulation of its expression is an important factor in the activity of the hypoxia-inducible factor pathway. Its modulation may help treat hypoxia-inducible factor driven aggressive prostate cancer. |
| first_indexed | 2024-03-07T05:54:34Z |
| format | Journal article |
| id | oxford-uuid:ea15459d-f63b-4968-825c-7a25b152039d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:54:34Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:ea15459d-f63b-4968-825c-7a25b152039d2022-03-27T10:59:02ZNuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ea15459d-f63b-4968-825c-7a25b152039dEnglishSymplectic Elements at Oxford2011Shaida, NChan, PTurley, HJones, CKanga, SRitchie, RMalone, PHarris, AFox, S PURPOSE: We determined the role of factor inhibiting hypoxia-inducible factor-1 in prostate cancer specimens. MATERIALS AND METHODS: A tissue microarray of 152 prostate cancers was constructed and stained for factor inhibiting hypoxia-inducible factor-1, hypoxia-inducible factor-1α and 2α, and glucose transporter 1 as a prototypical downstream target of hypoxia-inducible factor-1α. Correlation analysis was done between these variables, and between factor inhibiting hypoxia-inducible factor-1, and clinical and pathological variables, including prostate specific antigen as a surrogate of recurrence. RESULTS: Factor inhibiting hypoxia-inducible factor-1 was expressed in the cytoplasm and/or the nucleus in 86.5% of tumors, including exclusive cytoplasmic expression in 51.3% and exclusive nuclear expression in 5.3%. Any nuclear and exclusive expression of factor inhibiting hypoxia-inducible factor was associated with poor prognosis on univariate analysis (p = 0.007 and 0.042, respectively). On multivariate analysis men with nuclear expression in tumors were twice as likely to experience recurrence (p = 0.034). CONCLUSIONS: Factor inhibiting hypoxia-inducible factor-1 is widely expressed in prostate tumors. Its differential subcellular expression suggests that regulation of its expression is an important factor in the activity of the hypoxia-inducible factor pathway. Its modulation may help treat hypoxia-inducible factor driven aggressive prostate cancer. |
| spellingShingle | Shaida, N Chan, P Turley, H Jones, C Kanga, S Ritchie, R Malone, P Harris, A Fox, S Nuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis. |
| title | Nuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis. |
| title_full | Nuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis. |
| title_fullStr | Nuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis. |
| title_full_unstemmed | Nuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis. |
| title_short | Nuclear localization of factor inhibitor hypoxia-inducible factor in prostate cancer is associated with poor prognosis. |
| title_sort | nuclear localization of factor inhibitor hypoxia inducible factor in prostate cancer is associated with poor prognosis |
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