A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack.
BACKGROUND: Effective early management of patients with transient ischaemic attacks (TIA) is undermined by an inability to predict who is at highest early risk of stroke. METHODS: We derived a score for 7-day risk of stroke in a population-based cohort of patients (n=209) with a probable or definit...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2005
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| _version_ | 1797101664354697216 |
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| author | Rothwell, P Giles, M Flossmann, E Lovelock, C Redgrave, J Warlow, C Mehta, Z |
| author_facet | Rothwell, P Giles, M Flossmann, E Lovelock, C Redgrave, J Warlow, C Mehta, Z |
| author_sort | Rothwell, P |
| collection | OXFORD |
| description | BACKGROUND: Effective early management of patients with transient ischaemic attacks (TIA) is undermined by an inability to predict who is at highest early risk of stroke. METHODS: We derived a score for 7-day risk of stroke in a population-based cohort of patients (n=209) with a probable or definite TIA (Oxfordshire Community Stroke Project; OCSP), and validated the score in a similar population-based cohort (Oxford Vascular Study; OXVASC, n=190). We assessed likely clinical usefulness to front-line health services by using the score to stratify all patients with suspected TIA referred to OXVASC (n=378, outcome: 7-day risk of stroke) and to a hospital-based weekly TIA clinic (n=210; outcome: risk of stroke before appointment). RESULTS: A six-point score derived in the OCSP (age [> or =60 years=1], blood pressure [systolic >140 mm Hg and/or diastolic > or =90 mm Hg=1], clinical features [unilateral weakness=2, speech disturbance without weakness=1, other=0], and duration of symptoms in min [> or =60=2, 10-59=1, <10=0]; ABCD) was highly predictive of 7-day risk of stroke in OXVASC patients with probable or definite TIA (p<0.0001), in the OXVASC population-based cohort of all referrals with suspected TIA (p<0.0001), and in the hospital-based weekly TIA clinic-referred cohort (p=0.006). In the OXVASC suspected TIA cohort, 19 of 20 (95%) strokes occurred in 101 (27%) patients with a score of 5 or greater: 7-day risk was 0.4% (95% CI 0-1.1) in 274 (73%) patients with a score less than 5, 12.1% (4.2-20.0) in 66 (18%) with a score of 5, and 31.4% (16.0-46.8) in 35 (9%) with a score of 6. In the hospital-referred clinic cohort, 14 (7.5%) patients had a stroke before their scheduled appointment, all with a score of 4 or greater. CONCLUSIONS: Risk of stroke during the 7 days after TIA seems to be highly predictable. Although further validations and refinements are needed, the ABCD score can be used in routine clinical practice to identify high-risk individuals who need emergency investigation and treatment. |
| first_indexed | 2024-03-07T05:55:01Z |
| format | Journal article |
| id | oxford-uuid:ea39cc08-bd4c-498f-86cf-5d8fd0a4fdfd |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:55:01Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:ea39cc08-bd4c-498f-86cf-5d8fd0a4fdfd2022-03-27T11:00:24ZA simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ea39cc08-bd4c-498f-86cf-5d8fd0a4fdfdEnglishSymplectic Elements at Oxford2005Rothwell, PGiles, MFlossmann, ELovelock, CRedgrave, JWarlow, CMehta, Z BACKGROUND: Effective early management of patients with transient ischaemic attacks (TIA) is undermined by an inability to predict who is at highest early risk of stroke. METHODS: We derived a score for 7-day risk of stroke in a population-based cohort of patients (n=209) with a probable or definite TIA (Oxfordshire Community Stroke Project; OCSP), and validated the score in a similar population-based cohort (Oxford Vascular Study; OXVASC, n=190). We assessed likely clinical usefulness to front-line health services by using the score to stratify all patients with suspected TIA referred to OXVASC (n=378, outcome: 7-day risk of stroke) and to a hospital-based weekly TIA clinic (n=210; outcome: risk of stroke before appointment). RESULTS: A six-point score derived in the OCSP (age [> or =60 years=1], blood pressure [systolic >140 mm Hg and/or diastolic > or =90 mm Hg=1], clinical features [unilateral weakness=2, speech disturbance without weakness=1, other=0], and duration of symptoms in min [> or =60=2, 10-59=1, <10=0]; ABCD) was highly predictive of 7-day risk of stroke in OXVASC patients with probable or definite TIA (p<0.0001), in the OXVASC population-based cohort of all referrals with suspected TIA (p<0.0001), and in the hospital-based weekly TIA clinic-referred cohort (p=0.006). In the OXVASC suspected TIA cohort, 19 of 20 (95%) strokes occurred in 101 (27%) patients with a score of 5 or greater: 7-day risk was 0.4% (95% CI 0-1.1) in 274 (73%) patients with a score less than 5, 12.1% (4.2-20.0) in 66 (18%) with a score of 5, and 31.4% (16.0-46.8) in 35 (9%) with a score of 6. In the hospital-referred clinic cohort, 14 (7.5%) patients had a stroke before their scheduled appointment, all with a score of 4 or greater. CONCLUSIONS: Risk of stroke during the 7 days after TIA seems to be highly predictable. Although further validations and refinements are needed, the ABCD score can be used in routine clinical practice to identify high-risk individuals who need emergency investigation and treatment. |
| spellingShingle | Rothwell, P Giles, M Flossmann, E Lovelock, C Redgrave, J Warlow, C Mehta, Z A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. |
| title | A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. |
| title_full | A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. |
| title_fullStr | A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. |
| title_full_unstemmed | A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. |
| title_short | A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. |
| title_sort | simple score abcd to identify individuals at high early risk of stroke after transient ischaemic attack |
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