Principles of reconstructing the subclonal architecture of cancers

Principles of reconstructing the subclonal architecture of cancers

Most cancers evolve from a single founder cell through a series of clonal expansions that are driven by somatic mutations. These clonal expansions can lead to several coexisting subclones sharing subsets of mutations. Analysis of massively parallel sequencing data can infer a tumor's subclonal...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Dentro, S, Wedge, D, Van Loo, P
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	Cold Spring Harbor Laboratory Press 2017

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