Epistasis, core-genome disharmony, and adaptation in recombining bacteria

Epistasis, core-genome disharmony, and adaptation in recombining bacteria

<p>Recombination of short DNA fragments via horizontal gene transfer (HGT) can introduce beneficial alleles, create genomic disharmony through negative epistasis, and create adaptive gene combinations through positive epistasis. For non-core (accessory) genes, the negative epistatic cost is li...

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Main Authors: Taylor, AJ, Yahara, K, Pascoe, B, Ko, S, Mageiros, L, Mourkas, E, Calland, JK, Puranen, S, Hitchings, MD, Jolley, KA, Kobras, CM, Bayliss, S, Williams, NJ, van Vliet, AHM, Parkhill, J, Maiden, MCJ, Corander, J, Hurst, LD, Falush, D, Keim, P, Didelot, X, Kelly, DJ, Sheppard, SK
Format: Journal article
Language:English
Published: American Society for Microbiology 2024

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