Human immunodeficiency virus-specific T lymphocyte cell
Recent developments in HIV-specific CTL quantification (staining with MHC-epitopic peptide tetramers and IFNγ production) have shed new light on human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL). One week after infection, anti-HIV CTLs quickly appear, with a weak specificity...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | French |
| Published: |
2001
|
| _version_ | 1826302975105040384 |
|---|---|
| author | Oxenius, A Mclean, A Fischer, M Price, D Dawson, S Hafner, R Schneider, C Joller, H Hirschel, B Phillips, R Weber, R Günthard, H Battegay, M Bucher, H Bernasconi, E Piffaretti, J Bürgisser, P Francioli, P Pantaleo, G Rickenbach, M Telenti, A Egger, M Erb, P Klimkait, T Fierz, W |
| author_facet | Oxenius, A Mclean, A Fischer, M Price, D Dawson, S Hafner, R Schneider, C Joller, H Hirschel, B Phillips, R Weber, R Günthard, H Battegay, M Bucher, H Bernasconi, E Piffaretti, J Bürgisser, P Francioli, P Pantaleo, G Rickenbach, M Telenti, A Egger, M Erb, P Klimkait, T Fierz, W |
| author_sort | Oxenius, A |
| collection | OXFORD |
| description | Recent developments in HIV-specific CTL quantification (staining with MHC-epitopic peptide tetramers and IFNγ production) have shed new light on human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL). One week after infection, anti-HIV CTLs quickly appear, with a weak specificity spectrum which broaden afterwards. During the asymptomatic stage, an equilibrum between host and virus exists, characterized by vigourous CTL responses (frequencies: 10-2 to 10-3 CD8 T cells) directed against all HIV proteins and poor HIV replication. The ratio anti-HIV CTL : CD4 infected cells is 10:1, thus in favour of CTL action. When HIV viral load rises up, Aids stage is reached due to either viral escape or immune system exhaustion. Highly active antiretroviral therapies permit some immune reconstitution while effector CTLs decrease. Even if it is controled. HIV is still present in « viral reservoir ». |
| first_indexed | 2024-03-07T05:55:36Z |
| format | Journal article |
| id | oxford-uuid:ea61bbfe-4bc5-4608-875b-13ae6442d18b |
| institution | University of Oxford |
| language | French |
| last_indexed | 2024-03-07T05:55:36Z |
| publishDate | 2001 |
| record_format | dspace |
| spelling | oxford-uuid:ea61bbfe-4bc5-4608-875b-13ae6442d18b2022-03-27T11:01:57ZHuman immunodeficiency virus-specific T lymphocyte cellJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ea61bbfe-4bc5-4608-875b-13ae6442d18bFrenchSymplectic Elements at Oxford2001Oxenius, AMclean, AFischer, MPrice, DDawson, SHafner, RSchneider, CJoller, HHirschel, BPhillips, RWeber, RGünthard, HBattegay, MBucher, HBernasconi, EPiffaretti, JBürgisser, PFrancioli, PPantaleo, GRickenbach, MTelenti, AEgger, MErb, PKlimkait, TFierz, WRecent developments in HIV-specific CTL quantification (staining with MHC-epitopic peptide tetramers and IFNγ production) have shed new light on human immunodeficiency virus (HIV)-specific cytotoxic T lymphocytes (CTL). One week after infection, anti-HIV CTLs quickly appear, with a weak specificity spectrum which broaden afterwards. During the asymptomatic stage, an equilibrum between host and virus exists, characterized by vigourous CTL responses (frequencies: 10-2 to 10-3 CD8 T cells) directed against all HIV proteins and poor HIV replication. The ratio anti-HIV CTL : CD4 infected cells is 10:1, thus in favour of CTL action. When HIV viral load rises up, Aids stage is reached due to either viral escape or immune system exhaustion. Highly active antiretroviral therapies permit some immune reconstitution while effector CTLs decrease. Even if it is controled. HIV is still present in « viral reservoir ». |
| spellingShingle | Oxenius, A Mclean, A Fischer, M Price, D Dawson, S Hafner, R Schneider, C Joller, H Hirschel, B Phillips, R Weber, R Günthard, H Battegay, M Bucher, H Bernasconi, E Piffaretti, J Bürgisser, P Francioli, P Pantaleo, G Rickenbach, M Telenti, A Egger, M Erb, P Klimkait, T Fierz, W Human immunodeficiency virus-specific T lymphocyte cell |
| title | Human immunodeficiency virus-specific T lymphocyte cell |
| title_full | Human immunodeficiency virus-specific T lymphocyte cell |
| title_fullStr | Human immunodeficiency virus-specific T lymphocyte cell |
| title_full_unstemmed | Human immunodeficiency virus-specific T lymphocyte cell |
| title_short | Human immunodeficiency virus-specific T lymphocyte cell |
| title_sort | human immunodeficiency virus specific t lymphocyte cell |
| work_keys_str_mv | AT oxeniusa humanimmunodeficiencyvirusspecifictlymphocytecell AT mcleana humanimmunodeficiencyvirusspecifictlymphocytecell AT fischerm humanimmunodeficiencyvirusspecifictlymphocytecell AT priced humanimmunodeficiencyvirusspecifictlymphocytecell AT dawsons humanimmunodeficiencyvirusspecifictlymphocytecell AT hafnerr humanimmunodeficiencyvirusspecifictlymphocytecell AT schneiderc humanimmunodeficiencyvirusspecifictlymphocytecell AT jollerh humanimmunodeficiencyvirusspecifictlymphocytecell AT hirschelb humanimmunodeficiencyvirusspecifictlymphocytecell AT phillipsr humanimmunodeficiencyvirusspecifictlymphocytecell AT weberr humanimmunodeficiencyvirusspecifictlymphocytecell AT gunthardh humanimmunodeficiencyvirusspecifictlymphocytecell AT battegaym humanimmunodeficiencyvirusspecifictlymphocytecell AT bucherh humanimmunodeficiencyvirusspecifictlymphocytecell AT bernasconie humanimmunodeficiencyvirusspecifictlymphocytecell AT piffarettij humanimmunodeficiencyvirusspecifictlymphocytecell AT burgisserp humanimmunodeficiencyvirusspecifictlymphocytecell AT franciolip humanimmunodeficiencyvirusspecifictlymphocytecell AT pantaleog humanimmunodeficiencyvirusspecifictlymphocytecell AT rickenbachm humanimmunodeficiencyvirusspecifictlymphocytecell AT telentia humanimmunodeficiencyvirusspecifictlymphocytecell AT eggerm humanimmunodeficiencyvirusspecifictlymphocytecell AT erbp humanimmunodeficiencyvirusspecifictlymphocytecell AT klimkaitt humanimmunodeficiencyvirusspecifictlymphocytecell AT fierzw humanimmunodeficiencyvirusspecifictlymphocytecell |