Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)
Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tum...
| Автори: | , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
Wiley
2019
|
| _version_ | 1826303009230946304 |
|---|---|
| author | Patel, DM Jones, RR Booth, BJ Olsson, AC Kromhout, H Straif, K Vermeulen, R Tikellis, G Paltiel, O Golding, J Northstone, K Stoltenberg, C Håberg, SE Schüz, J Friesen, MC Ponsonby, A-L Lemeshow, S Linet, MS Magnus, P Olsen, J Olsen, SF Dwyer, T Stayner, LT Ward, MH International Childhood Cancer Cohort Consortium |
| author_facet | Patel, DM Jones, RR Booth, BJ Olsson, AC Kromhout, H Straif, K Vermeulen, R Tikellis, G Paltiel, O Golding, J Northstone, K Stoltenberg, C Håberg, SE Schüz, J Friesen, MC Ponsonby, A-L Lemeshow, S Linet, MS Magnus, P Olsen, J Olsen, SF Dwyer, T Stayner, LT Ward, MH International Childhood Cancer Cohort Consortium |
| author_sort | Patel, DM |
| collection | OXFORD |
| description | Parental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations‐1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animals HR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further. |
| first_indexed | 2024-03-07T05:56:07Z |
| format | Journal article |
| id | oxford-uuid:ea8c95d4-3242-4a9d-8509-d66ec6d8f0ee |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:56:07Z |
| publishDate | 2019 |
| publisher | Wiley |
| record_format | dspace |
| spelling | oxford-uuid:ea8c95d4-3242-4a9d-8509-d66ec6d8f0ee2022-03-27T11:03:15ZParental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C)Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:ea8c95d4-3242-4a9d-8509-d66ec6d8f0eeEnglishSymplectic Elements at OxfordWiley2019Patel, DMJones, RRBooth, BJOlsson, ACKromhout, HStraif, KVermeulen, RTikellis, GPaltiel, OGolding, JNorthstone, KStoltenberg, CHåberg, SESchüz, JFriesen, MCPonsonby, A-LLemeshow, SLinet, MSMagnus, POlsen, JOlsen, SFDwyer, TStayner, LTWard, MHInternational Childhood Cancer Cohort ConsortiumParental occupational exposures to pesticides, animals and organic dust have been associated with an increased risk of childhood cancer based mostly on case–control studies. We prospectively evaluated parental occupational exposures and risk of childhood leukemia and central nervous system (CNS) tumors in the International Childhood Cancer Cohort Consortium. We pooled data on 329,658 participants from birth cohorts in five countries (Australia, Denmark, Israel, Norway and United Kingdom). Parental occupational exposures during pregnancy were estimated by linking International Standard Classification of Occupations‐1988 job codes to the ALOHA+ job exposure matrix. Risk of childhood (<15 years) acute lymphoblastic leukemia (ALL; n = 129), acute myeloid leukemia (AML; n = 31) and CNS tumors (n = 158) was estimated using Cox proportional hazards models to generate hazard ratios (HR) and 95% confidence intervals (CI). Paternal exposures to pesticides and animals were associated with increased risk of childhood AML (herbicides HR = 3.22, 95% CI = 0.97–10.68; insecticides HR = 2.86, 95% CI = 0.99–8.23; animals HR = 3.89, 95% CI = 1.18–12.90), but not ALL or CNS tumors. Paternal exposure to organic dust was positively associated with AML (HR = 2.38 95% CI = 1.12–5.07), inversely associated with ALL (HR = 0.55, 95% CI = 0.31–0.99) and not associated with CNS tumors. Low exposure prevalence precluded evaluation of maternal pesticide and animal exposures; we observed no significant associations with organic dust exposure. This first prospective analysis of pooled birth cohorts and parental occupational exposures provides evidence for paternal agricultural exposures as childhood AML risk factors. The different risks for childhood ALL associated with maternal and paternal organic dust exposures should be investigated further. |
| spellingShingle | Patel, DM Jones, RR Booth, BJ Olsson, AC Kromhout, H Straif, K Vermeulen, R Tikellis, G Paltiel, O Golding, J Northstone, K Stoltenberg, C Håberg, SE Schüz, J Friesen, MC Ponsonby, A-L Lemeshow, S Linet, MS Magnus, P Olsen, J Olsen, SF Dwyer, T Stayner, LT Ward, MH International Childhood Cancer Cohort Consortium Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C) |
| title | Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C) |
| title_full | Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C) |
| title_fullStr | Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C) |
| title_full_unstemmed | Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C) |
| title_short | Parental occupational exposure to pesticides, animals and organic dust and risk of childhood leukemia and central nervous system tumors: Findings from the International Childhood Cancer Cohort Consortium (I4C) |
| title_sort | parental occupational exposure to pesticides animals and organic dust and risk of childhood leukemia and central nervous system tumors findings from the international childhood cancer cohort consortium i4c |
| work_keys_str_mv | AT pateldm parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT jonesrr parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT boothbj parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT olssonac parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT kromhouth parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT straifk parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT vermeulenr parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT tikellisg parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT paltielo parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT goldingj parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT northstonek parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT stoltenbergc parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT habergse parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT schuzj parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT friesenmc parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT ponsonbyal parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT lemeshows parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT linetms parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT magnusp parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT olsenj parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT olsensf parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT dwyert parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT staynerlt parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT wardmh parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c AT internationalchildhoodcancercohortconsortium parentaloccupationalexposuretopesticidesanimalsandorganicdustandriskofchildhoodleukemiaandcentralnervoussystemtumorsfindingsfromtheinternationalchildhoodcancercohortconsortiumi4c |