The Plasmodium falciparum Rh5 invasion protein complex reveals an excess of rare variant mutations

The Plasmodium falciparum Rh5 invasion protein complex reveals an excess of rare variant mutations

<strong>Background</strong> The invasion of the red blood cells by Plasmodium falciparum merozoites involves the interplay of several proteins that are also targets for vaccine development. The proteins PfRh5-PfRipr-PfCyRPA-Pfp113 assemble into a complex at the apical end of the merozoit...

Full description

Bibliographic Details
Main Authors:	Ndwiga, L, Osoti, V, Ochwedo, KO, Wamae, K, Bejon, P, Rayner, JC, Githinji, G, Ochola-Oyier, LI
Format:	Journal article
Language:	English
Published:	BioMed Central 2021

Similar Items

The Plasmodium falciparum Rh5 invasion protein complex reveals an excess of rare variant mutations
by: Leonard Ndwiga, et al.
Published: (2021-06-01)

Maintenance of high temporal Plasmodium falciparum genetic diversity and complexity of infection in asymptomatic and symptomatic infections in Kilifi, Kenya from 2007 to 2018
by: Kimenyi, KM, et al.
Published: (2022)

No evidence of P. falciparum K13 artemisinin conferring mutations over a 24-year analysis in Coastal Kenya, but a near complete reversion to chloroquine wild type parasites
by: Wamae, K, et al.
Published: (2019)

Amplicon sequencing as a potential surveillance tool for complexity of infection and drug resistance markers in Plasmodium falciparum asymptomatic infections
by: Wamae, K, et al.
Published: (2022)

A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa
by: Ndwiga, L, et al.
Published: (2021)

Maintenance of high temporal Plasmodium falciparum genetic diversity and complexity of infection in asymptomatic and symptomatic infections in Kilifi, Kenya from 2007 to 2018
by: Kelvin M. Kimenyi, et al.
Published: (2022-06-01)

A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa
by: Leonard Ndwiga, et al.
Published: (2021-08-01)

Low frequency of Plasmodium falciparum hrp2/3 deletions from symptomatic infections at a primary healthcare facility in Kilifi, Kenya
by: Dorcas Okanda, et al.
Published: (2023-02-01)

Transmission and age impact the risk of developing febrile malaria in children with asymptomatic Plasmodium falciparum parasitemia
by: Wamae, K, et al.
Published: (2018)

Understanding P. falciparum asymptomatic infections: a proposition for a transcriptomic approach
by: Kimenyi, KM, et al.
Published: (2019)

Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum
by: Kioko, M, et al.
Published: (2023)

Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya
by: Osoti, V, et al.
Published: (2025)

ONT sequencing identifies a high prevalence of crt sensitive, triple mutant dhfr and single mutant dhps parasites within an ANC population in Nigeria
by: Adebanjo Jonathan Adegbola, et al.
Published: (2024-10-01)

Few Plasmodium falciparum merozoite ligand and erythrocyte receptor pairs show evidence of balancing selection
by: Ochola-Oyier, L, et al.
Published: (2019)

Understanding P. falciparum Asymptomatic Infections: A Proposition for a Transcriptomic Approach
by: Kelvin M. Kimenyi, et al.
Published: (2019-10-01)

A cross-sectional analysis identifies a low prevalence of Plasmodium ovale species infections in symptomatic and asymptomatic individuals in Kilifi county, Kenya. [version 4; peer review: 2 approved]
by: Leonard Ndwiga, et al.
Published: (2024-09-01)

Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya
by: Victor Osoti, et al.
Published: (2025-01-01)

Comparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population.
by: Ochola-Oyier, L, et al.
Published: (2016)

Insights into the role of the Plasmodium falciparum reticulocyte binding protein RH1 in merozoite invasion.
by: Loh, Han Ping.
Published: (2012)

Extracellular vesicles could be a putative posttranscriptional regulatory mechanism that shapes intracellular RNA levels in Plasmodium falciparum
by: Mwikali Kioko, et al.
Published: (2023-10-01)

A full-length recombinant Plasmodium falciparum PfRH5 protein induces inhibitory antibodies that are effective across common PfRH5 genetic variants
by: Bustamante, L, et al.
Published: (2013)

Neutralization of Plasmodium falciparum merozoites by antibodies against PfRH5.
by: Douglas, A, et al.
Published: (2014)

A role for microtubules in Plasmodium falciparum merozoite invasion.
by: Bejon, P, et al.
Published: (1997)

Antibodies targeting the PfRH1 binding domain inhibit invasion of plasmodium falciparum merozoites
by: Iyer, Jayasree K., et al.
Published: (2011)

Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites.
by: Xiaohong Gao, et al.
Published: (2008-07-01)

Plasmodium falciparum erythrocyte invasion: combining function with immune evasion.
by: Gavin J Wright, et al.
Published: (2014-03-01)

Extreme mutation bias and high AT content in Plasmodium falciparum
by: Hamilton, W, et al.
Published: (2016)

Elucidation of functional significance of plasmodium falciparum reticulocyte binding like protein homologues - RH1, RH2A AND RH4 during merozoite invasion.
by: Karthigayan Gunalan.
Published: (2012)

Potential of RH5 Antisense on Plasmodium falciparum Proliferation Abatement
by: Sepand Razavi Vakhshourpour, et al.
Published: (2022-12-01)

Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion
by: Tony Triglia, et al.
Published: (2023-04-01)

Targeted amplicon deep sequencing for monitoring antimalarial resistance markers in western Kenya
by: Osoti, V, et al.
Published: (2022)

Functional insight the role of plasmodium falciparum reticulocyte blinding like protein homologues : RH2B and RH5 during merozoites invasion
by: Yaw, Aniweh
Published: (2016)

Temporal trends in prevalence of Plasmodium falciparum drug resistance alleles over two decades of changing antimalarial policy in coastal Kenya.
by: Okombo, J, et al.
Published: (2014)

P113 is a merozoite surface protein that binds the N terminus of Plasmodium falciparum RH5
by: Francis Galaway, et al.
Published: (2017-02-01)

Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial [version 4; peer review: 2 approved, 2 approved with reservations]
by: Mainga Hamaluba, et al.
Published: (2024-03-01)

Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial [version 3; peer review: 2 approved, 2 approved with reservations]
by: Mainga Hamaluba, et al.
Published: (2023-10-01)

Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host P. falciparum diversity throughout treatment in a clinical drug trial [version 2; peer review: 2 approved, 1 approved with reservations]
by: Mainga Hamaluba, et al.
Published: (2022-12-01)

Plasmodium falciparum merozoite invasion is inhibited by antibodies that target the PfRh2a and b binding domains.
by: Tony Triglia, et al.
Published: (2011-06-01)

Geographic-genetic analysis of Plasmodium falciparum parasite populations from surveys of primary school children in Western Kenya
by: Omedo, I, et al.
Published: (2017)

Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum
by: Crosnier, C, et al.
Published: (2011)