Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.

Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.

AIMS/HYPOTHESIS: Protein kinase C (PKC) regulates exocytosis in various secretory cells. Here we studied intracellular translocation of the PKC isoenzymes PKCalpha and PKCdelta, and investigated how activation of PKC influences glucagon secretion in mouse and human pancreatic alpha cells. METHODS:...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	De Marinis, Y, Zhang, E, Amisten, S, Taneera, J, Renström, E, Rorsman, P, Eliasson, L
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2010

Eitemau Tebyg

Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets.
gan: Catherine J Pears, et al.
Cyhoeddwyd: (2008-01-01)

Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets.
gan: Pears, C, et al.
Cyhoeddwyd: (2008)

Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.
gan: Barg, S, et al.
Cyhoeddwyd: (2000)

Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat alpha-cells by a protein kinase A-mediated mechanism.
gan: Ding, W, et al.
Cyhoeddwyd: (1997)

Dual effects of low and high concentrations of cAMP on glucagon secretion from mouse pancreatic A-cells
gan: Eliasson, L, et al.
Cyhoeddwyd: (2009)

Somatostatin but not insulin is an important paracrine regulator of glucagon secretion in rat A-cells
gan: Renstrom, E, et al.
Cyhoeddwyd: (1997)

Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.
gan: Ramracheya, R, et al.
Cyhoeddwyd: (2010)

Effects of glucose, GLP-1 and adrenaline on alpha cell electrical activity and glucagon secretion from mouse pancreatic islets
gan: Zhang, Q, et al.
Cyhoeddwyd: (2010)

Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.
gan: Gromada, J, et al.
Cyhoeddwyd: (1995)

Identification and characterization of single glucagon-secreting A-cells in a standard mouse islet preparation
gan: Barg, S, et al.
Cyhoeddwyd: (1999)

Pathways of Glucagon Secretion and Trafficking in the Pancreatic Alpha Cell: Novel Pathways, Proteins, and Targets for Hyperglucagonemia
gan: Farzad Asadi, et al.
Cyhoeddwyd: (2021-09-01)

Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors.
gan: Gromada, J, et al.
Cyhoeddwyd: (1997)

CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells
gan: Anna Edlund, et al.
Cyhoeddwyd: (2017-03-01)

Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion.
gan: MacDonald, P, et al.
Cyhoeddwyd: (2011)

Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion
gan: MacDonald, P, et al.
Cyhoeddwyd: (2011)

New insights into the regulation of glucagon secretion by glucagon-like peptide-1.
gan: Gromada, J, et al.
Cyhoeddwyd: (2004)

Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.
gan: Ma, X, et al.
Cyhoeddwyd: (2005)

Components of insulin secretion: lessons to be learnt from capacitance.
gan: Rorsman, P, et al.
Cyhoeddwyd: (1997)

Glucagon secretion from pancreatic α-cells
gan: Briant, L, et al.
Cyhoeddwyd: (2016)

Glucose decouples intracellular Ca2+ activity from glucagon secretion in mouse pancreatic islet alpha-cells.
gan: Sylvain J Le Marchand, et al.
Cyhoeddwyd: (2012-01-01)

The glucagon-producing alpha cell: an electrophysiologically exceptional cell.
gan: Braun, M, et al.
Cyhoeddwyd: (2010)

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans
gan: Macdonald, P, et al.
Cyhoeddwyd: (2007)

Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells.
gan: Renström, E, et al.
Cyhoeddwyd: (1997)

GLP-1 inhibits glucagon secretion from human alpha cells by a direct effect
gan: Ramracheya, R, et al.
Cyhoeddwyd: (2010)

Evidence from in situ human alpha-cells supporting intrinsic K-ATP channel-dependent regulation of glucagon secretion
gan: Macdonald, P, et al.
Cyhoeddwyd: (2006)

The Clinical Signifcance of Expression of ERCC1 and PKCalpha in Non-small Cell Lung Cancer
gan: Hong YANG, et al.
Cyhoeddwyd: (2010-03-01)

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.
gan: MacDonald, P, et al.
Cyhoeddwyd: (2007)

REGULATION OF EXOCYTOSIS IN THE PANCREATIC B-CELL - INTERACTIONS BETWEEN PKA AND PKC
gan: Eliasson, L, et al.
Cyhoeddwyd: (1993)

The Cell Physiology of Biphasic Insulin Secretion.
gan: Rorsman, P, et al.
Cyhoeddwyd: (2000)

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.
gan: Patrick E MacDonald, et al.
Cyhoeddwyd: (2007-06-01)

Exocytosis depends on granular chloride fluxes regulated by a sulfonylurea receptor-like protein in insulin-secreting B-cells
gan: Barg, S, et al.
Cyhoeddwyd: (1999)

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.
gan: De Marinis, Y, et al.
Cyhoeddwyd: (2010)

Activated Protein Kinase C (PKC) Is Persistently Trafficked with Epidermal Growth Factor (EGF) Receptor
gan: Carol A. Heckman, et al.
Cyhoeddwyd: (2020-09-01)

A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.
gan: Barg, S, et al.
Cyhoeddwyd: (2002)

K(ATP)-channels and glucose-regulated glucagon secretion.
gan: Rorsman, P, et al.
Cyhoeddwyd: (2008)

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?
gan: Walker, J, et al.
Cyhoeddwyd: (2011)

Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.
gan: Wendt, A, et al.
Cyhoeddwyd: (2004)

LOCAL INTRACELLULAR CA2+-GRADIENTS ASSOCIATED WITH CA2+ ENTRY INTO AND SECRETION FROM MOUSE PANCREATIC BETA-CELLS
gan: Bokvist, K, et al.
Cyhoeddwyd: (1993)

DIRECT EVIDENCE FOR THE EXISTENCE OF HOT-SPOTS OF SECRETION IN MOUSE PANCREATIC BETA-CELLS
gan: Bokvist, K, et al.
Cyhoeddwyd: (1994)

The endoplasmic reticulum plays a key role in α-cell intracellular Ca2+ dynamics and glucose-regulated glucagon secretion in mouse islets
gan: Acreman, S, et al.
Cyhoeddwyd: (2024)