Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.

Enhancement of glucagon secretion in mouse and human pancreatic alpha cells by protein kinase C (PKC) involves intracellular trafficking of PKCalpha and PKCdelta.

AIMS/HYPOTHESIS: Protein kinase C (PKC) regulates exocytosis in various secretory cells. Here we studied intracellular translocation of the PKC isoenzymes PKCalpha and PKCdelta, and investigated how activation of PKC influences glucagon secretion in mouse and human pancreatic alpha cells. METHODS:...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	De Marinis, Y, Zhang, E, Amisten, S, Taneera, J, Renström, E, Rorsman, P, Eliasson, L
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2010

Ижил төстэй зүйлс

Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets.
-н: Catherine J Pears, зэрэг
Хэвлэсэн: (2008-01-01)

Differential roles of the PKC novel isoforms, PKCdelta and PKCepsilon, in mouse and human platelets.
-н: Pears, C, зэрэг
Хэвлэсэн: (2008)

Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.
-н: Barg, S, зэрэг
Хэвлэсэн: (2000)

Glucagon-like peptide I and glucose-dependent insulinotropic polypeptide stimulate Ca2+-induced secretion in rat alpha-cells by a protein kinase A-mediated mechanism.
-н: Ding, W, зэрэг
Хэвлэсэн: (1997)

Dual effects of low and high concentrations of cAMP on glucagon secretion from mouse pancreatic A-cells
-н: Eliasson, L, зэрэг
Хэвлэсэн: (2009)

Somatostatin but not insulin is an important paracrine regulator of glucagon secretion in rat A-cells
-н: Renstrom, E, зэрэг
Хэвлэсэн: (1997)

Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human islets.
-н: Ramracheya, R, зэрэг
Хэвлэсэн: (2010)

Effects of glucose, GLP-1 and adrenaline on alpha cell electrical activity and glucagon secretion from mouse pancreatic islets
-н: Zhang, Q, зэрэг
Хэвлэсэн: (2010)

Glucagon-like peptide I increases cytoplasmic calcium in insulin-secreting beta TC3-cells by enhancement of intracellular calcium mobilization.
-н: Gromada, J, зэрэг
Хэвлэсэн: (1995)

Identification and characterization of single glucagon-secreting A-cells in a standard mouse islet preparation
-н: Barg, S, зэрэг
Хэвлэсэн: (1999)

Pathways of Glucagon Secretion and Trafficking in the Pancreatic Alpha Cell: Novel Pathways, Proteins, and Targets for Hyperglucagonemia
-н: Farzad Asadi, зэрэг
Хэвлэсэн: (2021-09-01)

Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors.
-н: Gromada, J, зэрэг
Хэвлэсэн: (1997)

CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells
-н: Anna Edlund, зэрэг
Хэвлэсэн: (2017-03-01)

Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion.
-н: MacDonald, P, зэрэг
Хэвлэсэн: (2011)

Per-arnt-sim (PAS) domain kinase (PASK) as a regulator of glucagon secretion
-н: MacDonald, P, зэрэг
Хэвлэсэн: (2011)

New insights into the regulation of glucagon secretion by glucagon-like peptide-1.
-н: Gromada, J, зэрэг
Хэвлэсэн: (2004)

Glucagon stimulates exocytosis in mouse and rat pancreatic alpha-cells by binding to glucagon receptors.
-н: Ma, X, зэрэг
Хэвлэсэн: (2005)

Components of insulin secretion: lessons to be learnt from capacitance.
-н: Rorsman, P, зэрэг
Хэвлэсэн: (1997)

Glucagon secretion from pancreatic α-cells
-н: Briant, L, зэрэг
Хэвлэсэн: (2016)

Glucose decouples intracellular Ca2+ activity from glucagon secretion in mouse pancreatic islet alpha-cells.
-н: Sylvain J Le Marchand, зэрэг
Хэвлэсэн: (2012-01-01)

The glucagon-producing alpha cell: an electrophysiologically exceptional cell.
-н: Braun, M, зэрэг
Хэвлэсэн: (2010)

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans
-н: Macdonald, P, зэрэг
Хэвлэсэн: (2007)

Protein kinase A-dependent and -independent stimulation of exocytosis by cAMP in mouse pancreatic B-cells.
-н: Renström, E, зэрэг
Хэвлэсэн: (1997)

GLP-1 inhibits glucagon secretion from human alpha cells by a direct effect
-н: Ramracheya, R, зэрэг
Хэвлэсэн: (2010)

Evidence from in situ human alpha-cells supporting intrinsic K-ATP channel-dependent regulation of glucagon secretion
-н: Macdonald, P, зэрэг
Хэвлэсэн: (2006)

The Clinical Signifcance of Expression of ERCC1 and PKCalpha in Non-small Cell Lung Cancer
-н: Hong YANG, зэрэг
Хэвлэсэн: (2010-03-01)

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.
-н: MacDonald, P, зэрэг
Хэвлэсэн: (2007)

REGULATION OF EXOCYTOSIS IN THE PANCREATIC B-CELL - INTERACTIONS BETWEEN PKA AND PKC
-н: Eliasson, L, зэрэг
Хэвлэсэн: (1993)

The Cell Physiology of Biphasic Insulin Secretion.
-н: Rorsman, P, зэрэг
Хэвлэсэн: (2000)

A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.
-н: Patrick E MacDonald, зэрэг
Хэвлэсэн: (2007-06-01)

Exocytosis depends on granular chloride fluxes regulated by a sulfonylurea receptor-like protein in insulin-secreting B-cells
-н: Barg, S, зэрэг
Хэвлэсэн: (1999)

GLP-1 inhibits and adrenaline stimulates glucagon release by differential modulation of N- and L-type Ca2+ channel-dependent exocytosis.
-н: De Marinis, Y, зэрэг
Хэвлэсэн: (2010)

Activated Protein Kinase C (PKC) Is Persistently Trafficked with Epidermal Growth Factor (EGF) Receptor
-н: Carol A. Heckman, зэрэг
Хэвлэсэн: (2020-09-01)

A subset of 50 secretory granules in close contact with L-type Ca2+ channels accounts for first-phase insulin secretion in mouse beta-cells.
-н: Barg, S, зэрэг
Хэвлэсэн: (2002)

K(ATP)-channels and glucose-regulated glucagon secretion.
-н: Rorsman, P, зэрэг
Хэвлэсэн: (2008)

Regulation of glucagon secretion by glucose: paracrine, intrinsic or both?
-н: Walker, J, зэрэг
Хэвлэсэн: (2011)

Glucose inhibition of glucagon secretion from rat alpha-cells is mediated by GABA released from neighboring beta-cells.
-н: Wendt, A, зэрэг
Хэвлэсэн: (2004)

LOCAL INTRACELLULAR CA2+-GRADIENTS ASSOCIATED WITH CA2+ ENTRY INTO AND SECRETION FROM MOUSE PANCREATIC BETA-CELLS
-н: Bokvist, K, зэрэг
Хэвлэсэн: (1993)

DIRECT EVIDENCE FOR THE EXISTENCE OF HOT-SPOTS OF SECRETION IN MOUSE PANCREATIC BETA-CELLS
-н: Bokvist, K, зэрэг
Хэвлэсэн: (1994)

The endoplasmic reticulum plays a key role in α-cell intracellular Ca2+ dynamics and glucose-regulated glucagon secretion in mouse islets
-н: Acreman, S, зэрэг
Хэвлэсэн: (2024)