MEK inhibitors block growth of lung tumors with mutations in Ataxia Telangiectasia Mutated

MEK inhibitors block growth of lung tumors with mutations in Ataxia Telangiectasia Mutated

Lung cancer is the leading cause of cancer deaths, and effective treatments are urgently needed. Loss-of-function mutations in the DNA damage response kinase ATM are common in lung adenocarcinoma but directly targeting these with drugs remains challenging. Here we report that ATM loss-of-function is...

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Príomhchruthaitheoirí:	Smida, M, Fece de la Cruz, F, Kerzendorfer, C, Muir, B, Konopka, T, Nijman, S
Formáid:	Journal article
Foilsithe / Cruthaithe:	Nature Publishing Group 2016

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