Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.
The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in...
| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Journal article |
| 言語: | English |
| 出版事項: |
2005
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| _version_ | 1826303101169041408 |
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| author | Thimme, R Appay, V Koschella, M Panther, E Roth, E Hislop, A Rickinson, AB Rowland-Jones, S Blum, H Pircher, H |
| author_facet | Thimme, R Appay, V Koschella, M Panther, E Roth, E Hislop, A Rickinson, AB Rowland-Jones, S Blum, H Pircher, H |
| author_sort | Thimme, R |
| collection | OXFORD |
| description | The killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells in mice and that virus-specific CD8+ T cells are mostly KLRG1+ in chronic human viral infections (human immunodeficiency virus, cytomegalovirus, and Epstein-Barr virus) but not in resolved infection (influenza virus). Thus, by using KLRG1 as a T-cell marker, our results suggest that the differentiation status and function of virus-specific CD8+ T cells are directly influenced by persistent antigen stimulation. |
| first_indexed | 2024-03-07T05:57:31Z |
| format | Journal article |
| id | oxford-uuid:eb09ff0f-9e6c-4dab-a32c-3c7a01ef109c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:57:31Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:eb09ff0f-9e6c-4dab-a32c-3c7a01ef109c2022-03-27T11:06:42ZIncreased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:eb09ff0f-9e6c-4dab-a32c-3c7a01ef109cEnglishSymplectic Elements at Oxford2005Thimme, RAppay, VKoschella, MPanther, ERoth, EHislop, ARickinson, ABRowland-Jones, SBlum, HPircher, HThe killer cell lectin-like receptor G1 (KLRG1) is a natural killer cell receptor expressed by T cells that exhibit impaired proliferative capacity. Here, we determined the KLRG1 expression by virus-specific T cells. We found that repetitive and persistent antigen stimulation leads to an increase in KLRG1 expression of virus-specific CD8+ T cells in mice and that virus-specific CD8+ T cells are mostly KLRG1+ in chronic human viral infections (human immunodeficiency virus, cytomegalovirus, and Epstein-Barr virus) but not in resolved infection (influenza virus). Thus, by using KLRG1 as a T-cell marker, our results suggest that the differentiation status and function of virus-specific CD8+ T cells are directly influenced by persistent antigen stimulation. |
| spellingShingle | Thimme, R Appay, V Koschella, M Panther, E Roth, E Hislop, A Rickinson, AB Rowland-Jones, S Blum, H Pircher, H Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. |
| title | Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. |
| title_full | Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. |
| title_fullStr | Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. |
| title_full_unstemmed | Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. |
| title_short | Increased expression of the NK cell receptor KLRG1 by virus-specific CD8 T cells during persistent antigen stimulation. |
| title_sort | increased expression of the nk cell receptor klrg1 by virus specific cd8 t cells during persistent antigen stimulation |
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