Drug‐induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann–Pick type C cells and mice
Most cells acquire cholesterol by endocytosis of circulating lowdensity lipoproteins (LDLs). After cholesteryl ester de-esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work suggested that the unconventional phospholipid l...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Udgivet: |
EMBO Press
2019
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