Genetic predisposition to an impaired metabolism of the branched chain amino acids and risk of type 2 diabetes: A Mendelian randomisation analysis

Genetic predisposition to an impaired metabolism of the branched chain amino acids and risk of type 2 diabetes: A Mendelian randomisation analysis

<p><strong>Background:</strong> Higher circulating levels of the branched chain amino acids (BCAA; i.e. isoleucine, leucine and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this association is causal. We undertook large-scale human g...

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Автори: Lotta, L, Scott, R, Sharp, S, Burgess, S, Luan, J, Tillin, T, Schmidt, A, Imamura, F, Stewart, I, Perry, J, Marney, L, Koulman, A, Karoly, E, Forouhi, N, Sjögren, R, Näslund, E, Zierath, J, Krook, A, Savage, D, Griffin, J, Chaturvedi, N, Hingorani, A, Khaw, K, Barroso, I, McCarthy, M, O'Rahilly, S, Wareham, N, Langenberg, C
Формат: Journal article
Опубліковано: Public Library of Science 2016

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