Genetic predisposition to an impaired metabolism of the branched chain amino acids and risk of type 2 diabetes: A Mendelian randomisation analysis

Genetic predisposition to an impaired metabolism of the branched chain amino acids and risk of type 2 diabetes: A Mendelian randomisation analysis

<p><strong>Background:</strong> Higher circulating levels of the branched chain amino acids (BCAA; i.e. isoleucine, leucine and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this association is causal. We undertook large-scale human g...

Descripció completa

Dades bibliogràfiques
Autors principals:	Lotta, L, Scott, R, Sharp, S, Burgess, S, Luan, J, Tillin, T, Schmidt, A, Imamura, F, Stewart, I, Perry, J, Marney, L, Koulman, A, Karoly, E, Forouhi, N, Sjögren, R, Näslund, E, Zierath, J, Krook, A, Savage, D, Griffin, J, Chaturvedi, N, Hingorani, A, Khaw, K, Barroso, I, McCarthy, M, O'Rahilly, S, Wareham, N, Langenberg, C
Format:	Journal article
Publicat:	Public Library of Science 2016

Ítems similars

Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.
per: Luca A Lotta, et al.
Publicat: (2016-11-01)

Prospective association of the Mediterranean diet with cardiovascular disease incidence and mortality and its population impact in a non-Mediterranean population: the EPIC-Norfolk study
per: Tong, T, et al.
Publicat: (2016)

Association of genetically enhanced lipoprotein lipase-mediated lipolysis and low-density lipoprotein cholesterol-lowering alleles with risk of coronary disease and type 2 diabetes
per: Lotta, L, et al.
Publicat: (2018)

Assessing the causal association of glycine with risk of cardio-metabolic diseases
per: Wittemans, L, et al.
Publicat: (2019)

Southall And Brent REvisited: Cohort profile of SABRE, a UK population-based comparison of cardiovascular disease and diabetes in people of European, Indian Asian and African Caribbean origins.
per: Tillin, T, et al.
Publicat: (2012)

A combination of metabolites predicts adherence to the Mediterranean diet pattern and its associations with insulin sensitivity and lipid homeostasis in the general population: the Fenland Study, United Kingdom
per: Tong, TYN, et al.
Publicat: (2019)

Association of genetically enhanced lipoprotein lipase–mediated lipolysis and low-density lipoprotein cholesterol–lowering alleles with risk of coronary disease and type 2 diabetes
per: Lotta, LA, et al.
Publicat: (2018)

Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study.
per: Shengxu Li, et al.
Publicat: (2010-08-01)

Electromagnetic theory : a critical examination of fundamentals/
per: O'Rahilly, Alfred
Publicat: (1965)

P10.11 MEAN ARTERIAL PRESSURE IS A STRONGER PREDICTOR OF STROKE IN SOUTH ASIAN THAN EUROPEAN MEN, INDEPENDENT OF OTHER CARDIOMETABOLIC RISK FACTORS; THE SABRE STUDY
per: S. Eastwood, et al.
Publicat: (2014-11-01)

Dietary cost associated with adherence to the Mediterranean diet, and its variation by socio-economic factors in the UK Fenland Study
per: Tong, Y, et al.
Publicat: (2018)

Predisposition to eating disorders in rural adolescents
per: T. A. Astakhova, et al.
Publicat: (2024-11-01)

Does type II diabetes arise from a major gene defect producing insulin resistance or beta cell dysfunction?
per: Turner, R, et al.
Publicat: (1989)

PARL Leu262Val is not associated with fasting insulin levels in UK populations.
per: Fawcett, K, et al.
Publicat: (2006)

State of the art in acute glaucoma attack predisposition issue
per: N. A. Bakunina
Publicat: (2022-07-01)

SPECIFIC FEATURES OF GENETIC PREDISPOSITION TO ASTHMA
per: I. I. Cherkashina, et al.
Publicat: (2016-12-01)

Ethnic differences in disability prevalence and their determinants studied over a 20-year period: a cohort study.
per: Emily D Williams, et al.
Publicat: (2012-01-01)

EXOME SEQUENCING AND THE DIAGNOSTICS OF COMPLEX DISEASE PREDISPOSITION IN PREVENTIVE MEDICINE
per: N. V. Shcherbakova, et al.
Publicat: (2013-12-01)

Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries
per: Li, SX, et al.
Publicat: (2018)

Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation
per: Romain Barres, et al.
Publicat: (2013-05-01)

THE ROLE OF THE HEREDITARY PREDISPOSITION IN THE DEVELOPMENT OF AORTA COARCTATION
per: T. N. Tatarinova, et al.
Publicat: (2012-11-01)

Constraints of learning : limitations and predisposition /
per: Hinde, J. Stevenson
Publicat: (1973)

Metabolic abnormalities in children of non-insulin dependent diabetics.
per: O'Rahilly, S, et al.
Publicat: (1986)

The embryonic human brain : an atlas of developmental stages /
per: O'Rahilly, Ronan, et al.
Publicat: (2006)

Insulin resistance : insulin action and its disturbances in disease /
per: Kumar, Sudhesh, et al.
Publicat: (2005)

Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
per: Lotta, L, et al.
Publicat: (2016)

Predisposition to cancer and radiosensitivity
per: P. Pichierri, et al.
Publicat: (2000-12-01)

Application of structural model of glucose-insulin relations to assess beta-cell function and insulin sensitivity.
per: Turner, R, et al.
Publicat: (1990)

CIGMA as a tool in the study of NIDDM.
per: Turner, R, et al.
Publicat: (1988)

Genetic predisposition for cervical cancer
per: T. V. Rotaru, et al.
Publicat: (2020-07-01)

Association between circulating 25-hydroxyvitamin D and cardiometabolic risk factors in adults in rural and urban settings
per: Camille M. Mba, et al.
Publicat: (2022-07-01)

Pathogenesis of NIDDM--a disease of deficient insulin secretion.
per: Turner, R, et al.
Publicat: (1988)

Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples
per: Den Hoed, M, et al.
Publicat: (2013)

Phenotypic consequences of a genetic predisposition to enhanced nitric oxide signaling
per: Emdin, C, et al.
Publicat: (2017)

Inherited predisposition to myeloid malignancies
per: Lucy A. Godley
Publicat: (2019-09-01)

P4.24 DIETARY INORGANIC NITRATE LOWERS CENTRAL BLOOD PRESSURE
per: S. Kukadia, et al.
Publicat: (2013-11-01)

Hereditary predisposition to kidney cancer: cancer syndromes, multisystemic disorders, and nephropathies
per: G. A. Yanus, et al.
Publicat: (2023-07-01)

Genetic predisposition to a recurrent course of vulvovaginal candidiasis
per: Sh M Pogosyan, et al.
Publicat: (2017-08-01)

Genetic predisposition to chronic lymphocytic leukemia
per: Philip J. Law, et al.
Publicat: (2019-06-01)

An appreciation of Robert Turner.
per: O'Rahilly, S, et al.
Publicat: (2008)