Functionalised pyrrolidinones by conjugate addition of stabilised enolates and reformatsky reagents

Functionalised pyrrolidinones by conjugate addition of stabilised enolates and reformatsky reagents

The α,β-unsaturated lactam 1b has been found to readily undergo conjugate addition reactions with a range of stabilised carbon nucleophiles and Reformatsky reagents under mild conditions in good yield with high diastereoselectivity. This method provides a simple and versatile approach to highly func...

Descripció completa

Dades bibliogràfiques
Autors principals:	Dyer, J, Keeling, S, Moloney, M
Format:	Journal article
Idioma:	English
Publicat:	1996

Ítems similars

Efficient reformatsky conjugate additions to alkylidene malonates and malonamides
per: Bentz, E, et al.
Publicat: (2007)

Functionalised pyrrolidinones derived from (S)-pyroglutamic acid
per: Beard, M, et al.
Publicat: (1996)

Conjugate addition of nitrogen nucleophiles to an unsaturated pyrrolidinone.
per: Chan, P, et al.
Publicat: (1998)

Functionalised pyrrolidinones derived from (S)-pyroglutamic acid by cycloaddition reactions
per: Bailey, J, et al.
Publicat: (1997)

Conjugate addition of nitrogen nucleophiles to an alpha,beta-unsaturated pyrrolidinone
per: Chan, P, et al.
Publicat: (1997)

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 2. Conformationally constrained kainoid analogues
per: Dyer, J, et al.
Publicat: (2000)

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 1. Conformationally constrained glutamate
per: Bailey, J, et al.
Publicat: (2000)

REFORMATSKY-TYPE REACTION WITH NEW CALCIUM REAGENTS BY USING CALCIUM ATOM - THF CO-CONDENSATES
per: Yokoyama†, Yasuo, et al.
Publicat: (2000-11-01)

A CONCISE APPROACH TO FUNCTIONALIZED, HOMOCHIRAL PYRROLIDINONES
per: Bamford, M, et al.
Publicat: (1995)

Enolates ambushed – asymmetric tandem conjugate addition and subsequent enolate trapping with conventional and less traditional electrophiles
per: Péter Kisszékelyi, et al.
Publicat: (2023-05-01)

Recent Developments in the Reformatsky-Claisen Rearrangement
per: Susumi Hatakeyama, et al.
Publicat: (2012-11-01)

Supramolecular networks stabilise and functionalise black phosphorus
per: Vladimir V. Korolkov, et al.
Publicat: (2017-11-01)

Stereoselective conjugate addition of lithium and titanium enolates to gamma-alkoxy enones
per: Bernardi, A, et al.
Publicat: (1996)

Recent developments in the asymmetric Reformatsky-type reaction
per: Hélène Pellissier
Publicat: (2018-02-01)

Novel chiral pyrrolidinone scaffolds derived from threonine with antibacterial activity
per: Anwar, M, et al.
Publicat: (2010)

Pyrrolidinones derived from (S)-pyroglutamic acid: penmacric acid and analogues.
per: Anwar, M, et al.
Publicat: (2003)

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 3. beta-aminopyrrolidinones
per: Chan, P, et al.
Publicat: (2001)

Sidewall functionalisation of carbon nanotubes by addition of diarylcarbene derivatives
per: Luksirikul, P, et al.
Publicat: (2011)

Pyrrolidinones derived from (S)-pyroglutamic acid. Part 4. alpha,beta-diaminopyrrolidinones
per: Chan, P, et al.
Publicat: (2001)

Carbohydrate-derived aminoalcohol ligands for asymmetric Reformatsky reactions
per: Emmerson, D, et al.
Publicat: (2005)

N‐Functionalised Imidazoles as Stabilisers for Metal Nanoparticles in Catalysis and Anion Binding
per: Dr. Christopher J. Serpell, et al.
Publicat: (2020-06-01)

Functionalised polymers by covalent surface modification
per: Moloney, MG
Publicat: (2008)

Synthesis of the pyrrolidinone core of oxazolomycin A
per: O'Riordan, TJC
Publicat: (2009)

Difluoroalkylation of tertiary amides and lactams by an iridium-catalyzed reductive reformatsky reaction
per: Biallas, P, et al.
Publicat: (2022)

Microwave-enhanced alpha-functionalisation of tetramates
per: Moloney, M, et al.
Publicat: (2008)

Trimethylcyanosilane as a Convenient Reagent for the Preparation of Trimethylsilyl Enol Ethers of 1,3-Diketones
per: Jin-Cong Zhuo
Publicat: (1999-10-01)

Synthesis of the pyrrolidinone core of KSM-2690 B.
per: Donohoe, T, et al.
Publicat: (2007)

Synthesis of the pyrrolidinone core of KSM-2690 B
per: Donohoe, T, et al.
Publicat: (2007)

Pyrrolidinodiones in Enol-Ugi, Enol-Passerini, and Anomalous Enol-Passerini Condensations
per: Ana G. Neo, et al.
Publicat: (2019-03-01)

Pyruvate enolate arylation and alkylation: OBO ester protected pyruvates as useful reagents in organic synthesis
per: Alves Esteves, C, et al.
Publicat: (2017)

Synthesis of New Optically Active 2-Pyrrolidinones
per: Thomas Mavromoustakos, et al.
Publicat: (2012-12-01)

Synthesis and characterisation of C-60 derivatives containing functionalised anthraquinone groups and an unusual fullerene-stabilised cation
per: Bidell, W, et al.
Publicat: (1998)

Lead(IV) reagents: An underestimated class of reagents in synthesis?
per: Moloney, M
Publicat: (2001)

Highly Catalytic Enantioselective Reformatsky Reaction with Aldehydes and Ketones Using an Available Prolinol Ligand
per: Lu Ouyang, et al.
Publicat: (2020-06-01)

Those who started our history. A.N. Reformatsky and S.G. Krapivin
per: L. G. Vasicheva
Publicat: (2011-12-01)

Computer-Assisted Design and Synthetic Applications of Chiral Enol Borinates: Novel, Highly Enantioselective Aldol Reagents
per: Gennari Cesare, et al.
Publicat: (1998-01-01)

An Increased Understanding of Enolate Additions under Mechanochemical Conditions
per: Heather Hopgood, et al.
Publicat: (2017-04-01)

Asymmetric conjugate addition of alkylzirconium reagents to α,β-unsaturated lactones.
per: Maciver, E, et al.
Publicat: (2014)

Phosphoramidite ligand design for the enantioselective conjugate addition of alkylzirconium reagents to enones
per: Roth, PMC
Publicat: (2014)

Enantiopure bicyclic piperidinones: stereoselectivity in lactam enolate alkylations.
per: Brewster, A, et al.
Publicat: (2004)