HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.

HIF-1α is a protective factor in conditional PHD2-deficient mice suffering from severe HIF-2α-induced excessive erythropoiesis.

Erythropoiesis must be tightly balanced to guarantee adequate oxygen delivery to all tissues in the body. This process relies predominantly on the hormone erythropoietin (EPO) and its transcription factor hypoxia inducible factor (HIF). Accumulating evidence suggests that oxygen-sensitive prolyl hyd...

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Hlavní autoři: Franke, K, Kalucka, J, Mamlouk, S, Singh, R, Muschter, A, Weidemann, A, Iyengar, V, Jahn, S, Wieczorek, K, Geiger, K, Muders, M, Sykes, A, Poitz, D, Ripich, T, Otto, T, Bergmann, S, Breier, G, Baretton, G, Fong, G, Greaves, D, Bornstein, S, Chavakis, T, Fandrey, J, Gassmann, M, Wielockx, B
Médium: Journal article
Jazyk:English
Vydáno: 2013

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