Neural correlates of movement generation in the 'at-risk mental state'.
OBJECTIVE: People with 'prodromal' symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task. METHOD...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2010
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| _version_ | 1797101856897368064 |
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| author | Broome, MR Matthiasson, P Fusar-Poli, P Woolley, J Johns, L Tabraham, P Bramon, E Valmaggia, L Williams, S Brammer, M Chitnis, X McGuire, P |
| author_facet | Broome, MR Matthiasson, P Fusar-Poli, P Woolley, J Johns, L Tabraham, P Bramon, E Valmaggia, L Williams, S Brammer, M Chitnis, X McGuire, P |
| author_sort | Broome, MR |
| collection | OXFORD |
| description | OBJECTIVE: People with 'prodromal' symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task. METHOD: Cross-sectional comparison of individuals with an ARMS (n = 17), patients with first episode schizophreniform psychosis (n = 10) and healthy volunteers (n = 15). Subjects were studied using functional MRI while they performed a random movement generation paradigm. RESULTS: During random movement generation, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than in the first episode group. CONCLUSION: The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have recently presented with psychosis but less severe. |
| first_indexed | 2024-03-07T05:57:51Z |
| format | Journal article |
| id | oxford-uuid:eb248de4-0685-4728-be44-1e325dbdc127 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:57:51Z |
| publishDate | 2010 |
| record_format | dspace |
| spelling | oxford-uuid:eb248de4-0685-4728-be44-1e325dbdc1272022-03-27T11:07:30ZNeural correlates of movement generation in the 'at-risk mental state'.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:eb248de4-0685-4728-be44-1e325dbdc127EnglishSymplectic Elements at Oxford2010Broome, MRMatthiasson, PFusar-Poli, PWoolley, JJohns, LTabraham, PBramon, EValmaggia, LWilliams, SBrammer, MChitnis, XMcGuire, POBJECTIVE: People with 'prodromal' symptoms have a very high risk of developing psychosis. We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task. METHOD: Cross-sectional comparison of individuals with an ARMS (n = 17), patients with first episode schizophreniform psychosis (n = 10) and healthy volunteers (n = 15). Subjects were studied using functional MRI while they performed a random movement generation paradigm. RESULTS: During random movement generation, the ARMS group showed less activation in the left inferior parietal cortex than controls, but greater activation than in the first episode group. CONCLUSION: The ARMS is associated with abnormalities of regional brain function that are qualitatively similar to those in patients who have recently presented with psychosis but less severe. |
| spellingShingle | Broome, MR Matthiasson, P Fusar-Poli, P Woolley, J Johns, L Tabraham, P Bramon, E Valmaggia, L Williams, S Brammer, M Chitnis, X McGuire, P Neural correlates of movement generation in the 'at-risk mental state'. |
| title | Neural correlates of movement generation in the 'at-risk mental state'. |
| title_full | Neural correlates of movement generation in the 'at-risk mental state'. |
| title_fullStr | Neural correlates of movement generation in the 'at-risk mental state'. |
| title_full_unstemmed | Neural correlates of movement generation in the 'at-risk mental state'. |
| title_short | Neural correlates of movement generation in the 'at-risk mental state'. |
| title_sort | neural correlates of movement generation in the at risk mental state |
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