Advances in treatment of bacterial meningitis.
Bacterial meningitis kills or maims about a fifth of people with the disease. Early antibiotic treatment improves outcomes, but the effectiveness of widely available antibiotics is threatened by global emergence of multidrug-resistant bacteria. New antibiotics, such as fluoroquinolones, could have a...
| Main Authors: | , , , |
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| 格式: | Journal article |
| 語言: | English |
| 出版: |
2012
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| _version_ | 1826303125915435008 |
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| author | van de Beek, D Brouwer, M Thwaites, G Tunkel, A |
| author_facet | van de Beek, D Brouwer, M Thwaites, G Tunkel, A |
| author_sort | van de Beek, D |
| collection | OXFORD |
| description | Bacterial meningitis kills or maims about a fifth of people with the disease. Early antibiotic treatment improves outcomes, but the effectiveness of widely available antibiotics is threatened by global emergence of multidrug-resistant bacteria. New antibiotics, such as fluoroquinolones, could have a role in these circumstances, but clinical data to support this notion are scarce. Additionally, whether or not adjunctive anti-inflammatory therapies (eg, dexamethasone) improve outcomes in patients with bacterial meningitis remains controversial; in resource-poor regions, where the disease burden is highest, dexamethasone is ineffective. Other adjunctive therapeutic strategies, such as glycerol, paracetamol, and induction of hypothermia, are being tested further. Therefore, bacterial meningitis is a substantial and evolving therapeutic challenge. We review this challenge, with a focus on strategies to optimise antibiotic efficacy in view of increasingly drug-resistant bacteria, and discuss the role of current and future adjunctive therapies. |
| first_indexed | 2024-03-07T05:57:54Z |
| format | Journal article |
| id | oxford-uuid:eb294d91-0f8c-4bbf-a136-21574bdfaac2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:57:54Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:eb294d91-0f8c-4bbf-a136-21574bdfaac22022-03-27T11:07:33ZAdvances in treatment of bacterial meningitis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:eb294d91-0f8c-4bbf-a136-21574bdfaac2EnglishSymplectic Elements at Oxford2012van de Beek, DBrouwer, MThwaites, GTunkel, ABacterial meningitis kills or maims about a fifth of people with the disease. Early antibiotic treatment improves outcomes, but the effectiveness of widely available antibiotics is threatened by global emergence of multidrug-resistant bacteria. New antibiotics, such as fluoroquinolones, could have a role in these circumstances, but clinical data to support this notion are scarce. Additionally, whether or not adjunctive anti-inflammatory therapies (eg, dexamethasone) improve outcomes in patients with bacterial meningitis remains controversial; in resource-poor regions, where the disease burden is highest, dexamethasone is ineffective. Other adjunctive therapeutic strategies, such as glycerol, paracetamol, and induction of hypothermia, are being tested further. Therefore, bacterial meningitis is a substantial and evolving therapeutic challenge. We review this challenge, with a focus on strategies to optimise antibiotic efficacy in view of increasingly drug-resistant bacteria, and discuss the role of current and future adjunctive therapies. |
| spellingShingle | van de Beek, D Brouwer, M Thwaites, G Tunkel, A Advances in treatment of bacterial meningitis. |
| title | Advances in treatment of bacterial meningitis. |
| title_full | Advances in treatment of bacterial meningitis. |
| title_fullStr | Advances in treatment of bacterial meningitis. |
| title_full_unstemmed | Advances in treatment of bacterial meningitis. |
| title_short | Advances in treatment of bacterial meningitis. |
| title_sort | advances in treatment of bacterial meningitis |
| work_keys_str_mv | AT vandebeekd advancesintreatmentofbacterialmeningitis AT brouwerm advancesintreatmentofbacterialmeningitis AT thwaitesg advancesintreatmentofbacterialmeningitis AT tunkela advancesintreatmentofbacterialmeningitis |