In silico tools to aid medicinal chemistry: optimising bromodomain inhibitors
<p>Development of ligands for bromodomains has expanded our understanding of gene regulation and epigenetic links to disease. These acetylated lysine ‘reader’ domains are found within larger macromolecules that are involved in gene transcription and degradation. This thesis looks to employ...
المؤلف الرئيسي: | Bluck, J |
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مؤلفون آخرون: | Biggin, P |
التنسيق: | أطروحة |
منشور في: |
2019
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مواد مشابهة
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Epigenetic mechanisms in silico: understanding demethylation and rational design of bromodomain inhibitors
حسب: Coelho, W
منشور في: (2017) -
Development of small molecule CREBBP bromodomain ligands using medicinal chemistry-based approaches
حسب: Moroglu, M
منشور في: (2020) -
Emerging tools to investigate bromodomain functions
حسب: Kougnassoukou Tchara, P, وآخرون
منشور في: (2019) -
Developing inhibitors of bromodomain-histone interactions
حسب: Hewings, D
منشور في: (2014) -
Small-molecule bromodomain inhibitors for cancer therapy
حسب: Qi, J, وآخرون
منشور في: (2010)