In silico tools to aid medicinal chemistry: optimising bromodomain inhibitors
<p>Development of ligands for bromodomains has expanded our understanding of gene regulation and epigenetic links to disease. These acetylated lysine ‘reader’ domains are found within larger macromolecules that are involved in gene transcription and degradation. This thesis looks to employ...
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| 格式: | Thesis |
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2019
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