Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis.
BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a disease with a widely varying prognosis. The majority of patients survive about 3 years, but a significant number survive for 10 years or more, leading to problems in clinical trial design. OBJECTIVE: To demonstrate that simple clinical variables...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2002
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| _version_ | 1826303145332965376 |
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| author | Turner, M Bakker, M Sham, P Shaw, C Leigh, P Al-Chalabi, A |
| author_facet | Turner, M Bakker, M Sham, P Shaw, C Leigh, P Al-Chalabi, A |
| author_sort | Turner, M |
| collection | OXFORD |
| description | BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a disease with a widely varying prognosis. The majority of patients survive about 3 years, but a significant number survive for 10 years or more, leading to problems in clinical trial design. OBJECTIVE: To demonstrate that simple clinical variables can be used to construct a robust predictive model for survival, and to assess the effect of a known treatment within this model. METHODS: We carried out a retrospective multivariate modelling of a database of 841 patients with ALS seen over a 10-year period in a specialist motor neuron disorders clinic. The use of riluzole was tested as a prognostic factor within the model. RESULTS: A prognostic score generated from one cohort of patients predicted survival for a second cohort of patients (r(2) = 0.78). Prognostic variables included site of onset, age of onset, time from symptom onset to diagnosis, and El Escorial category at presentation. Riluzole therapy was an independently significant prognostic factor (relative risk of death 0.48, P < 0.0001, model chi(2) 297, P < 0.0001). CONCLUSIONS: Clinical databases can be used to generate multivariate prognostic models in ALS. Such models could be used to predict survival, to improve criteria for matching of patients in future clinical trials, and to test the impact of interventions. |
| first_indexed | 2024-03-07T05:58:12Z |
| format | Journal article |
| id | oxford-uuid:eb413aca-8f1c-47cf-a775-bf67cd4b7a58 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:58:12Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:eb413aca-8f1c-47cf-a775-bf67cd4b7a582022-03-27T11:08:16ZPrognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:eb413aca-8f1c-47cf-a775-bf67cd4b7a58EnglishSymplectic Elements at Oxford2002Turner, MBakker, MSham, PShaw, CLeigh, PAl-Chalabi, ABACKGROUND: Amyotrophic lateral sclerosis (ALS) is a disease with a widely varying prognosis. The majority of patients survive about 3 years, but a significant number survive for 10 years or more, leading to problems in clinical trial design. OBJECTIVE: To demonstrate that simple clinical variables can be used to construct a robust predictive model for survival, and to assess the effect of a known treatment within this model. METHODS: We carried out a retrospective multivariate modelling of a database of 841 patients with ALS seen over a 10-year period in a specialist motor neuron disorders clinic. The use of riluzole was tested as a prognostic factor within the model. RESULTS: A prognostic score generated from one cohort of patients predicted survival for a second cohort of patients (r(2) = 0.78). Prognostic variables included site of onset, age of onset, time from symptom onset to diagnosis, and El Escorial category at presentation. Riluzole therapy was an independently significant prognostic factor (relative risk of death 0.48, P < 0.0001, model chi(2) 297, P < 0.0001). CONCLUSIONS: Clinical databases can be used to generate multivariate prognostic models in ALS. Such models could be used to predict survival, to improve criteria for matching of patients in future clinical trials, and to test the impact of interventions. |
| spellingShingle | Turner, M Bakker, M Sham, P Shaw, C Leigh, P Al-Chalabi, A Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis. |
| title | Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis. |
| title_full | Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis. |
| title_fullStr | Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis. |
| title_full_unstemmed | Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis. |
| title_short | Prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis. |
| title_sort | prognostic modelling of therapeutic interventions in amyotrophic lateral sclerosis |
| work_keys_str_mv | AT turnerm prognosticmodellingoftherapeuticinterventionsinamyotrophiclateralsclerosis AT bakkerm prognosticmodellingoftherapeuticinterventionsinamyotrophiclateralsclerosis AT shamp prognosticmodellingoftherapeuticinterventionsinamyotrophiclateralsclerosis AT shawc prognosticmodellingoftherapeuticinterventionsinamyotrophiclateralsclerosis AT leighp prognosticmodellingoftherapeuticinterventionsinamyotrophiclateralsclerosis AT alchalabia prognosticmodellingoftherapeuticinterventionsinamyotrophiclateralsclerosis |