Mechanical force induces mitochondrial fission
Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive networks constantly remodeled by fission and...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
eLife Sciences Publications
2017
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| _version_ | 1797101912817926144 |
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| author | Helle, S Feng, Q Aebersold, M Hirt, L Grüter, R Vahid, A Sirianni, A Mostowy, S Snedeker, J Šarić, A Idema, T Zambelli, T Kornmann, B |
| author_facet | Helle, S Feng, Q Aebersold, M Hirt, L Grüter, R Vahid, A Sirianni, A Mostowy, S Snedeker, J Šarić, A Idema, T Zambelli, T Kornmann, B |
| author_sort | Helle, S |
| collection | OXFORD |
| description | Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive networks constantly remodeled by fission and fusion. Here, we show that mitochondrial fission is triggered by mechanical forces. Mechano-stimulation of mitochondria - via encounter with motile intracellular pathogens, via external pressure applied by an atomic force microscope, or via cell migration across uneven microsurfaces - results in the recruitment of the mitochondrial fission machinery, and subsequent division. We propose that MFF, owing to affinity for narrow mitochondria, acts as a membrane-bound force sensor to recruit the fission machinery to mechanically strained sites. Thus, mitochondria adapt to the environment by sensing and responding to biomechanical cues. Our findings that mechanical triggers can be coupled to biochemical responses in membrane dynamics may explain how organelles orderly cohabit in the crowded cytoplasm. |
| first_indexed | 2024-03-07T05:58:35Z |
| format | Journal article |
| id | oxford-uuid:eb663838-87ec-454b-9b5e-4e28c7f25571 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:58:35Z |
| publishDate | 2017 |
| publisher | eLife Sciences Publications |
| record_format | dspace |
| spelling | oxford-uuid:eb663838-87ec-454b-9b5e-4e28c7f255712022-03-27T11:09:18ZMechanical force induces mitochondrial fissionJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:eb663838-87ec-454b-9b5e-4e28c7f25571EnglishSymplectic Elements at OxfordeLife Sciences Publications2017Helle, SFeng, QAebersold, MHirt, LGrüter, RVahid, ASirianni, AMostowy, SSnedeker, JŠarić, AIdema, TZambelli, TKornmann, BEukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing and entangling with each other in such limited space. Mitochondria form extensive networks constantly remodeled by fission and fusion. Here, we show that mitochondrial fission is triggered by mechanical forces. Mechano-stimulation of mitochondria - via encounter with motile intracellular pathogens, via external pressure applied by an atomic force microscope, or via cell migration across uneven microsurfaces - results in the recruitment of the mitochondrial fission machinery, and subsequent division. We propose that MFF, owing to affinity for narrow mitochondria, acts as a membrane-bound force sensor to recruit the fission machinery to mechanically strained sites. Thus, mitochondria adapt to the environment by sensing and responding to biomechanical cues. Our findings that mechanical triggers can be coupled to biochemical responses in membrane dynamics may explain how organelles orderly cohabit in the crowded cytoplasm. |
| spellingShingle | Helle, S Feng, Q Aebersold, M Hirt, L Grüter, R Vahid, A Sirianni, A Mostowy, S Snedeker, J Šarić, A Idema, T Zambelli, T Kornmann, B Mechanical force induces mitochondrial fission |
| title | Mechanical force induces mitochondrial fission |
| title_full | Mechanical force induces mitochondrial fission |
| title_fullStr | Mechanical force induces mitochondrial fission |
| title_full_unstemmed | Mechanical force induces mitochondrial fission |
| title_short | Mechanical force induces mitochondrial fission |
| title_sort | mechanical force induces mitochondrial fission |
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