Increasing the survival of dendritic cells in vivo does not replace the requirement for CD4+ T cell help during primary CD8+ T cell responses.

Increasing the survival of dendritic cells in vivo does not replace the requirement for CD4+ T cell help during primary CD8+ T cell responses.

The survival of dendritic cells (DC) in vivo determines the duration of Ag presentation and is critical in determining the strength and magnitude of the resulting T cell response. We used a mouse model to show that Ag-loaded C57BL/6 DC (MHC class II(+/+) (MHC II(+/+))) that reach the lymph node surv...

Descripció completa

Dades bibliogràfiques
Autors principals:	Matthews, K, Qin, J, Yang, J, Hermans, I, Palmowski, M, Cerundolo, V, Ronchese, F
Format:	Journal article
Idioma:	English
Publicat:	2007

Ítems similars

CpG-matured murine plasmacytoid dendritic cells are capable of in vivo priming of functional CD8 T cell responses to endogenous but not exogenous antigens.
per: Salio, M, et al.
Publicat: (2004)

NKT cells enhance CD4+ and CD8+ T cell responses to soluble antigen in vivo through direct interaction with dendritic cells.
per: Hermans, I, et al.
Publicat: (2003)

CTL priming by CD8(+) and CD8(-) dendritic cells in vivo.
per: Ruedl, C, et al.
Publicat: (1999)

CD8(+) T cells mediate CD40-independent maturation of dendritic cells in vivo.
per: Ruedl, C, et al.
Publicat: (1999)

Requirement of mature dendritic cells for efficient activation of influenza A-specific memory CD8+ T cells.
per: Larsson, M, et al.
Publicat: (2000)

Kinetic and mechanistic requirements for helping CD8 T cells.
per: Agnellini, P, et al.
Publicat: (2008)

Induction of CD4+ T-cell responses by dendritic cells in vivo
per: Suri, R, et al.
Publicat: (1998)

Mature dendritic cells prime functionally superior melan-A-specific CD8+ lymphocytes as compared with nonprofessional APC.
per: Salio, M, et al.
Publicat: (2001)

Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help.
per: Marcus O Butler, et al.
Publicat: (2012-01-01)

Differential Requirement for CD70 and CD80/CD86 in Dendritic Cellmediated Activation of Tumor Tolerized CD8 T Cells
per: Barnkob, Mike Stein, et al.
Publicat: (2012)

Langerin+ CD8α+ Dendritic Cells Drive Early CD8+ T Cell Activation and IL-12 Production During Systemic Bacterial Infection
per: Kelly A. Prendergast, et al.
Publicat: (2018-05-01)

B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A.
per: Bergmann, H, et al.
Publicat: (2013)

Immature dendritic cells induce alternative CD4(+) T-cell responses in vivo.
per: Suri, R, et al.
Publicat: (2001)

Plasmacytoid dendritic cells prime IFN-gamma-secreting melanoma-specific CD8 lymphocytes and are found in primary melanoma lesions.
per: Salio, M, et al.
Publicat: (2003)

CD4+ T-cell help is required for effective CD8+ T cell-mediated resolution of acute viral hepatitis in mice.
per: Tanja Trautmann, et al.
Publicat: (2014-01-01)

Exploiting the role of endogenous lymphoid-resident dendritic cells in the priming of NKT cells and CD8+ T cells to dendritic cell-based vaccines.
per: Troels R Petersen, et al.
Publicat: (2011-03-01)

Dendritic cell ICAM-1 strengthens synapses with CD8 T cells but is not required for their early differentiation
per: Anita Sapoznikov, et al.
Publicat: (2023-08-01)

Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo.
per: Luckashenak, N, et al.
Publicat: (2008)

CD45 is required for type I IFN production by dendritic cells.
per: Montoya, M, et al.
Publicat: (2006)

Regulatory T cells inhibit stable contacts between CD4+ T cells and dendritic cells in vivo.
per: Tadokoro, C, et al.
Publicat: (2006)

CD8+ T cell priming by dendritic cell vaccines requires antigen transfer to endogenous antigen presenting cells.
per: Alice W Yewdall, et al.
Publicat: (2010-06-01)

Type 1 conventional dendritic cells and interferons are required for spontaneous CD4+ and CD8+ T‐cell protective responses to breast cancer
per: Raphaël Mattiuz, et al.
Publicat: (2021-01-01)

CD8+ T cell migration to the skin requires CD4+ help in a murine model of contact hypersensitivity.
per: Nanna Fyhrquist, et al.
Publicat: (2012-01-01)

Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses.
per: Lopes, L, et al.
Publicat: (2008)

CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responses.
per: Hui Li, et al.
Publicat: (2019-01-01)

CD4+ T cell help creates memory CD8+ T cells with innate and help-independent recall capacities
per: Tomasz Ahrends, et al.
Publicat: (2019-12-01)

Dendritic Cells and CD8 T Cell Immunity in Tumor Microenvironment
per: Chunmei Fu, et al.
Publicat: (2018-12-01)

T Cell Help Amplifies Innate Signals in CD8+ DCs for Optimal CD8+ T Cell Priming
per: Marie Greyer, et al.
Publicat: (2016-01-01)

Human CD141+ Dendritic Cell and CD1c+ Dendritic Cell Undergo Concordant Early Genetic Programming after Activation in Humanized Mice In Vivo
per: Yoshihito Minoda, et al.
Publicat: (2017-10-01)

Toxoplasma gondii: CD8 T Cells Cry for CD4 Help
per: Imtiaz A. Khan, et al.
Publicat: (2019-05-01)

Mature dendritic cells differentiated in the presence of interferon-beta and interleukin-3 prime functional antigen-specific CD8 T cells.
per: Renneson, J, et al.
Publicat: (2005)

Splenic dendritic cell subsets prime and boost CD8 T cells and are involved in the generation of effector CD8 T cells.
per: Behboudi, S, et al.
Publicat: (2004)

Expression of the Phosphatase Ppef2 Controls Survival and Function of CD8+ Dendritic Cells
per: Markus Zwick, et al.
Publicat: (2019-02-01)

Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming
per: Dieke van Dinther, et al.
Publicat: (2018-02-01)

In vivo T cell activation induces the formation of CD209(+) PDL-2(+) dendritic cells.
per: Matthew G Davidson, et al.
Publicat: (2013-01-01)

Murine melanoma-infiltrating dendritic cells are defective in antigen presenting function regardless of the presence of CD4CD25 regulatory T cells.
per: Haley Ataera, et al.
Publicat: (2011-03-01)

A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs
per: Kieran English, et al.
Publicat: (2024-02-01)

BYSTANDER PROLIFERATION OF CD8+ T-CELLS IN-VIVO
per: Tough, D, et al.
Publicat: (1995)

Type 1 conventional CD103+ dendritic cells control effector CD8+ T cell migration, survival, and memory responses during influenza infection
per: Ng, See Liang, et al.
Publicat: (2019)

Type 1 Conventional CD103+ Dendritic Cells Control Effector CD8+ T Cell Migration, Survival, and Memory Responses During Influenza Infection
per: See Liang Ng, et al.
Publicat: (2018-12-01)