Increasing the survival of dendritic cells in vivo does not replace the requirement for CD4+ T cell help during primary CD8+ T cell responses.

Increasing the survival of dendritic cells in vivo does not replace the requirement for CD4+ T cell help during primary CD8+ T cell responses.

The survival of dendritic cells (DC) in vivo determines the duration of Ag presentation and is critical in determining the strength and magnitude of the resulting T cell response. We used a mouse model to show that Ag-loaded C57BL/6 DC (MHC class II(+/+) (MHC II(+/+))) that reach the lymph node surv...

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Những tác giả chính:	Matthews, K, Qin, J, Yang, J, Hermans, I, Palmowski, M, Cerundolo, V, Ronchese, F
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2007

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