Discovery of TNF-α as a therapeutic target in rheumatoid arthritis: Preclinical and clinical studies
The development of effective new treatments is greatly facilitated by the understanding of the mechanisms of disease. In rheumatoid arthritis, there has been progress in understanding its immunology, the HLA class II predisposition including the 'shared epitope' and more recently in unders...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2002
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| _version_ | 1826303184061071360 |
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| author | Feldmann, M Maini, R |
| author_facet | Feldmann, M Maini, R |
| author_sort | Feldmann, M |
| collection | OXFORD |
| description | The development of effective new treatments is greatly facilitated by the understanding of the mechanisms of disease. In rheumatoid arthritis, there has been progress in understanding its immunology, the HLA class II predisposition including the 'shared epitope' and more recently in understanding the importance of proinflammatory cytokines. Here we review our work in defining TNFα as a therapeutic target in rheumatoid arthritis, from an understanding of molecular pathogenesis in vitro, to formal proof in the clinic in vivo. There is now extensive clinical use of anti-TNFα biologicals for severe rheumatoid arthritis in the US and Europe. © 2002 Éditions scientifiques et médicales Elsevier SAS. |
| first_indexed | 2024-03-07T05:58:48Z |
| format | Journal article |
| id | oxford-uuid:eb75327b-6970-4202-b176-8e6acc632ec5 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T05:58:48Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:eb75327b-6970-4202-b176-8e6acc632ec52022-03-27T11:09:46ZDiscovery of TNF-α as a therapeutic target in rheumatoid arthritis: Preclinical and clinical studiesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:eb75327b-6970-4202-b176-8e6acc632ec5EnglishSymplectic Elements at Oxford2002Feldmann, MMaini, RThe development of effective new treatments is greatly facilitated by the understanding of the mechanisms of disease. In rheumatoid arthritis, there has been progress in understanding its immunology, the HLA class II predisposition including the 'shared epitope' and more recently in understanding the importance of proinflammatory cytokines. Here we review our work in defining TNFα as a therapeutic target in rheumatoid arthritis, from an understanding of molecular pathogenesis in vitro, to formal proof in the clinic in vivo. There is now extensive clinical use of anti-TNFα biologicals for severe rheumatoid arthritis in the US and Europe. © 2002 Éditions scientifiques et médicales Elsevier SAS. |
| spellingShingle | Feldmann, M Maini, R Discovery of TNF-α as a therapeutic target in rheumatoid arthritis: Preclinical and clinical studies |
| title | Discovery of TNF-α as a therapeutic target in rheumatoid arthritis: Preclinical and clinical studies |
| title_full | Discovery of TNF-α as a therapeutic target in rheumatoid arthritis: Preclinical and clinical studies |
| title_fullStr | Discovery of TNF-α as a therapeutic target in rheumatoid arthritis: Preclinical and clinical studies |
| title_full_unstemmed | Discovery of TNF-α as a therapeutic target in rheumatoid arthritis: Preclinical and clinical studies |
| title_short | Discovery of TNF-α as a therapeutic target in rheumatoid arthritis: Preclinical and clinical studies |
| title_sort | discovery of tnf α as a therapeutic target in rheumatoid arthritis preclinical and clinical studies |
| work_keys_str_mv | AT feldmannm discoveryoftnfaasatherapeutictargetinrheumatoidarthritispreclinicalandclinicalstudies AT mainir discoveryoftnfaasatherapeutictargetinrheumatoidarthritispreclinicalandclinicalstudies |